Tadalafil – Cialis
Tadalafil, commonly marketed as Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension, belongs to the class of medications known as phosphodiesterase type 5 (PDE5) inhibitors.
Mechanism of Action
- Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE5), which typically degrades cyclic guanosine monophosphate (cGMP).
- With sexual arousal, nitric oxide (NO) elevates cGMP levels in the penis.
- This results in the relaxation of smooth muscle and enhanced blood flow, facilitating the achievement and maintenance of an erection.
Indications
- Mainly indicated for treating erectile dysfunction in men.
- Also effective for alleviating symptoms of benign prostatic hyperplasia (BPH) and managing pulmonary arterial hypertension as Adcirca.
Onset of Action
- Tadalafil typically starts working within 30 minutes to 1 hour after ingestion.
Duration of Action
- Its effects can persist for up to 36 hours, earning it the nickname “weekend pill.”
- This extended duration allows for flexible sexual activity within that time frame if arousal occurs.
Dosage
- The recommended dose for erectile dysfunction is usually 10 mg or 20 mg taken on an as-needed basis about 30 minutes prior to sexual activity.
- For managing BPH, a daily dose of 5 mg is typically prescribed.
Side Effects
- Common adverse effects may encompass headache, facial flushing, indigestion (including nausea and diarrhea), dizziness, back pain, and muscle discomfort.
- In rare cases, serious side effects like sudden vision or hearing loss may occur.
Contraindications
- Avoid concurrent use with nitrates (e.g., nitroglycerin) due to the risk of severe hypotension.
- Not recommended for individuals with significant cardiovascular issues, recent heart attack, or stroke.
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