Tadalafil – Cialis
Tadalafil is a potent medication classified as a phosphodiesterase type 5 (PDE5) inhibitor, renowned under the trade names Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension.
Mechanism of Action
- Tadalafil inhibits the enzyme PDE5, which is responsible for breaking down cyclic guanosine monophosphate (cGMP).
- During sexual excitement, the body’s release of nitric oxide (NO) elevates cGMP levels.
- This facilitates the relaxation of penis blood vessel smooth muscles, increasing blood flow and enabling an erection.
Indications
- Tadalafil is primarily prescribed for men experiencing erectile dysfunction.
- Additionally, it treats benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension when dispensed as Adcirca.
Onset of Action
- Tadalafil typically acts swiftly, with effects manifesting within 30 minutes to 1 hour after ingestion.
Duration of Action
- The efficacy of Tadalafil may persist for up to 36 hours, rendering it popularly known as the “weekend pill.”
- Men can achieve and sustain an erection for this duration, provided they undergo sexual stimulation.
Dosage
- For erectile dysfunction, the recommended dosage is 10 mg or 20 mg taken about 30 minutes prior to planned sexual activity.
- In treating BPH, a daily dose of 5 mg is typically suggested.
Side Effects
- Common adverse reactions may encompass headache, facial flushing, indigestion (including nausea and diarrhea), dizziness, muscle discomfort, and back pain.
- Occasionally, serious side effects like sudden vision or hearing loss can occur.
Contraindications
- Tadalafil should not be combined with nitrates (e.g., nitroglycerin) due to the risk of severe hypotension.
- It is contraindicated in individuals with significant cardiovascular issues, recent heart attacks, or strokes.
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