Sildenafil
Sildenafil, commonly known as Viagra, is a potent medication classified as a phosphodiesterase type 5 (PDE5) inhibitor, primarily utilized for enhancing sexual health.
Mechanism of Action
- Sildenafil effectively inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for degrading cyclic guanosine monophosphate (cGMP). During sexual arousal, the release of nitric oxide (NO) elevates cGMP levels, facilitating the relaxation of smooth muscle in blood vessels and promoting increased blood flow to the penis.
- This action enables men to achieve and sustain an erection.
Indications
- The primary use of sildenafil is to treat erectile dysfunction in men.
- Additionally, it may be prescribed under the name Revatio for managing arterial hypertension.
Onset of Action
- Sildenafil begins to take effect swiftly, generally within 30 minutes, although it may take up to an hour for some individuals.
Duration of Action
- The effects of sildenafil typically last between 4 to 5 hours, allowing ample time for achieving and maintaining an erection.
Dosage
- The recommended starting dose of sildenafil is 50 mg, adjustable based on the individual’s response and requirements.
- This dose should ideally be taken approximately 30 minutes to 1 hour before engaging in sexual activity.
Side Effects
- Common side effects may include headache, facial flushing, indigestion (such as nausea and diarrhea), visual disturbances (including blurred vision and alterations in color perception), elevated blood pressure, and in rare cases, hearing loss or changes.
Contraindications
- Sildenafil is contraindicated in conjunction with nitrates (such as nitroglycerin) due to the risk of significant blood pressure drops. It should also be avoided by individuals with serious heart issues, recent myocardial infarction, or stroke.
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