Sildenafil
Sildenafil, commonly known by the brand name Viagra, is a prominent medication categorized as a phosphodiesterase type 5 (PDE5) inhibitor.
Discover the key characteristics of sildenafil:
Mechanism of Action
- Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5), responsible for the breakdown of cyclic guanosine monophosphate (cGMP). This process enhances blood flow to the penis during sexual arousal, leading to smooth muscle relaxation and a stronger erection.
- This mechanism ensures effective erection attainment and maintenance.
Indications
- Sildenafil is primarily prescribed for the treatment of erectile dysfunction in men.
- It is also utilized in managing arterial hypertension under the formulation Revatio.
Onset of Action
- Sildenafil typically begins to work within 30 minutes, although it can take up to 1 hour for some individuals.
Duration of Action
- The effects of sildenafil last approximately 4 to 5 hours, allowing ample time to achieve and sustain an erection.
Dosage
- The recommended starting dose is 50 mg, which may be adjusted based on individual response.
- It is advisable to take the dose about 30 minutes to 1 hour prior to anticipated sexual activity.
Side Effects
- Common adverse effects include headache, facial flushing, dyspepsia (nausea, diarrhea), visual disturbances (blurred vision, color vision alterations), elevated blood pressure, and rarely, hearing loss or alterations in hearing.
Contraindications
- Sildenafil should not be used in conjunction with nitrates (e.g., nitroglycerin) due to the risk of significant blood pressure drops.
- This medication is contraindicated in patients with severe cardiovascular issues, recent myocardial infarction, or stroke.
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