Sildenafil
Sildenafil, commonly known as Viagra, is a prominent medication categorized as a phosphodiesterase type 5 (PDE5) inhibitor.
Mechanism of Action
- Sildenafil functions by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for degrading cyclic guanosine monophosphate (cGMP). During sexual arousal, the release of nitric oxide (NO) elevates cGMP levels, leading to relaxation of smooth muscle in blood vessels and enhanced blood flow to the penis.
- This process facilitates the achievement and maintenance of an erection.
Indications
- This medication is primarily indicated for the treatment of erectile dysfunction in men.
- Additionally, it may be utilized in the management of arterial hypertension under the brand name Revatio.
Onset of Action
- Sildenafil showcases a rapid onset of action, usually effective within 30 minutes, though it may take up to 1 hour for some individuals.
Duration of Action
- The effects typically last between 4 to 5 hours, allowing for adequate time to achieve and sustain an erection.
Dosage
- The recommended initial dosage of sildenafil is 50 mg, which can be adjusted based on individual needs and responses.
- This dose should be administered approximately 30 minutes to 1 hour prior to sexual activity.
Side Effects
- Common side effects may include headache, facial flushing, indigestion (e.g., nausea, diarrhea), vision changes (e.g., blurred vision, color perception changes), elevated blood pressure, and in rare cases, alterations in hearing.
Contraindications
- Sildenafil is contraindicated in combination with nitrates (e.g., nitroglycerin) due to the risk of significant blood pressure drops. It is also not recommended for patients with severe heart conditions or those who have recently experienced a myocardial infarction or stroke.
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