Sildenafil
Sildenafil, commonly recognized by its brand name Viagra, is a member of the phosphodiesterase type 5 (PDE5) inhibitor class of medications. Its primary function is to support erectile function in men suffering from erectile dysfunction.
Mechanism of Action
- Sildenafil effectively inhibits the enzyme PDE5, which is responsible for degrading cyclic guanosine monophosphate (cGMP). During sexual arousal, nitric oxide (NO) release in the penile region escalates cGMP levels, facilitating the relaxation of smooth muscle in blood vessels and promoting increased blood flow to the penis.
- This physiological process enables the achievement and maintenance of an erection.
Indications
- Primarily, sildenafil is prescribed to manage erectile dysfunction in men.
- Additionally, it is utilized in treating pulmonary arterial hypertension under the brand name Revatio.
Onset of Action
- The onset of sildenafil is notably rapid, typically starting to work within 30 minutes to 1 hour after ingestion.
Duration of Action
- Sildenafil’s effects generally last between 4 to 5 hours, which is adequate for attaining and sustaining an erection.
Dosage
- The standard initiation dose for sildenafil is 50 mg, adjustable based on individual efficacy and tolerance.
- This dosage should be administered approximately 30 minutes to 1 hour prior to anticipated sexual activity.
Side Effects
- Noteworthy side effects may encompass headache, facial flushing, dyspepsia (including nausea and diarrhea), alterations in vision (like blurred or color vision changes), elevated blood pressure, and in rare cases, hearing impairment or modifications.
Contraindications
- Sildenafil should not be co-administered with nitrates (e.g., nitroglycerin) due to the risk of significant hypotension. It is also contraindicated in patients with serious cardiovascular conditions, recent heart attack, or stroke.
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