Tadalafil – Cialis
Tadalafil is a renowned medication classified as a phosphodiesterase type 5 (PDE5) inhibitor. It is commonly referred to by its brand name, Cialis, for erectile dysfunction treatment, and Adcirca for addressing pulmonary arterial hypertension.
Mechanism of Action
- Tadalafil inhibits the enzyme PDE5, responsible for breaking down cyclic guanosine monophosphate (cGMP).
- In response to sexual stimulation, the release of nitric oxide (NO) enhances cGMP levels in penile tissues.
- This process leads to the relaxation of smooth muscles in blood vessels, promoting increased blood flow to the penis, facilitating an erection.
Indications
- Primarily prescribed for erectile dysfunction in men.
- Effective for treating benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension in its Adcirca form.
Onset of Action
- Typically, Tadalafil takes effect within 30 minutes to 1 hour post-ingestion.
Duration of Action
- Known for its prolonged impact, Tadalafil‘s effects can linger up to 36 hours, earning it the nickname “weekend pill.”
- Men can maintain erections throughout this period with sexual stimulation.
Dosage
- The standard dosage for erectile dysfunction ranges from 10 mg to 20 mg, typically administered approximately 30 minutes before planned sexual activity.
- For BPH, a daily dose of 5 mg is generally recommended.
Side Effects
- Individuals may experience common side effects such as headache, facial flushing, indigestion (including nausea and diarrhea), dizziness, muscle pain, and backache.
- In rare cases, serious side effects like sudden vision or hearing loss may arise.
Contraindications
- Do not combine Tadalafil with nitrates (e.g., nitroglycerin) due to the risk of dangerously low blood pressure.
- Contraindicated for individuals with severe heart issues or recent myocardial infarction or stroke.
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