Nandrolone Phenylpropionate
Nandrolone phenylpropionate is a potent injectable form of the anabolic steroid nandrolone. Its properties closely resemble those of Deca-Durabolin, which is based on the slower-acting nandrolone decanoate. The key distinction is the release speed of nandrolone into the bloodstream; while nandrolone decanoate provides a sustained release for about 3 weeks, nandrolone phenylpropionate is effective for approximately one week. This allows Deca-Durabolin to be administered once every 2-3 weeks, whereas Durabolin requires injections every few days to weekly. Both compounds are favored by athletes and bodybuilders for promoting strength and lean muscle gain with minimal estrogenic or androgenic side effects.
Structural Characteristics
Nandrolone phenylpropionate features a modified structure of nandrolone, with a propionic phenyl ester attached to the 17-beta hydroxyl group. Esterified steroids are less polar and are absorbed more slowly following injection. Once in circulation, the ester detaches, resulting in free (active) nandrolone. This design extends the therapeutic window, enabling less frequent injections compared to free steroids. Post deep intramuscular injection, nandrolone phenylpropionate causes a significant spike in nandrolone levels within 24-48 hours, tapering back to baseline within a week.
Side Effects (Estrogenic)
Nandrolone has a low propensity for estrogen conversion, estimated at about 20% compared to testosterone. Though the liver can convert nandrolone to estradiol, other active sites like adipose tissue are less prone to this transformation. Thus, estrogen-related side effects are considerably lower with nandrolone. Higher doses may elevate estrogen levels, leading to side effects like water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate can help manage these effects, or an aromatase inhibitor like Arimidex (anastrozole) may be utilized to inhibit estrogen synthesis. However, aromatase inhibitors can be costly and may negatively impact blood lipids.
It’s important to note that nandrolone exhibits progestin activity. Being a c-19 steroid, it binds effectively to its receptor, leading to weight gain and potential negative feedback on testosterone production. The interaction between nandrolone and estrogen can trigger gynecomastia even at low estrogen levels, and adequate anti-estrogen therapy can mitigate these effects.
Side Effects (Androgenic)
Despite its classification as an anabolic steroid, nandrolone can cause androgenic side effects, especially at higher doses. This includes oily skin, acne, and increased body and facial hair. Additionally, anabolic/androgenic steroids may exacerbate male pattern baldness. Women may experience virilizing effects, such as voice deepening, irregular menstruation, skin texture alteration, and clitoral enlargement. Nandrolone’s androgenic activity is lower than that of more potent agents like testosterone, resulting in a higher threshold for strong androgenic side effects. However, it can suppress libido in males when not combined with another androgen.
In androgen-sensitive tissues such as the scalp and prostate, nandrolone’s relative androgenicity diminishes due to its conversion to dihydronandrolone (DHN) via the 5-alpha reductase enzyme. The use of a 5-alpha reductase inhibitor, like finasteride, with nandrolone may increase the likelihood of androgenic side effects, so caution is advised.
Side Effects (Hepatotoxicity)
Nandrolone is not 17-alpha alkylated, which makes it unlikely to cause hepatotoxic effects in healthy individuals.
Side Effects (Cardiovascular)
Anabolic/androgenic steroids can adversely affect serum cholesterol levels, leading to a decrease in HDL (good cholesterol) and an increase in LDL (bad cholesterol), potentially heightening the risk of arteriosclerosis. The effect on serum lipids depends on dosage, administration route, steroid type, and hepatic metabolism resistance. Research shows a 600mg weekly dose of nandrolone decanoate leading to a 26% drop in HDL cholesterol, slightly exceeding the reduction noted with testosterone enanthate. Nandrolone decanoate is still considered to be less severe on serum lipids compared to 17-alpha alkylated substances. It’s also important to be aware of its potential impacts on blood pressure and triglycerides, which can elevate cardiovascular disease and myocardial infarction risks.
Side Effects (Testosterone Suppression)
Like all anabolic/androgenic steroids, nandrolone can suppress endogenous testosterone production when taken in muscle-building doses. Studies have shown that a 100mg weekly dose of nandrolone decanoate can cause a 57% reduction in serum testosterone, increasing to 70% at 300mg weekly. The progestational activity of nandrolone plays a significant role in this suppression, even with its low estrogen conversion potential. Without testosterone-stimulating agents, testosterone levels generally normalize within 2-6 months post-therapy. However, prolonged hypogonadotrophic hypogonadism may emerge from steroid misuse, necessitating medical intervention.
Administration (Men)
For anabolic effects, initial usage guidelines suggested a dosage of 25-50mg weekly for 12 weeks. For physique or performance enhancement, doses typically range from 200-400mg weekly, administered in cycles of 8-12 weeks. This amount generally results in noticeable increases in lean muscle mass and strength. Given the rapid action of the phenylpropionate ester, the weekly dosage is usually divided into two applications spaced evenly apart.
Administration (Women)
In general, a dosage of 25-50mg weekly for 12 weeks is recommended. For physique or performance enhancement, the most common dosage is 50mg weekly, given as a single injection, taken for cycles lasting 4-6 weeks. Caution is advised against higher doses or extended use due to the risk of androgenic side effects. Although it has a lower androgenic profile, virilization symptoms may still occur; thus, immediate discontinuation of nandrolone phenylpropionate is essential if these symptoms develop to prevent permanent changes.
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