Oxandrolone – Anavar
Anavar, renowned as a gentle anabolic steroid, is favored by athletes and bodybuilders for its weight gain potential. Its popularity stems from the fact that it does not convert to estrogen, significantly reducing the risk of gynecomastia and water retention compared to other steroids.
First introduced in the North American market nearly 50 years ago, Anavar was originally used to treat various infertility disorders, anemia, and wasting illnesses in hospitalized patients. While its clinical use has declined, Anavar presents notable advantages: it avoids estrogen conversion and minimizes disruption to the hypothalamic pituitary axis. This means users often escape common steroid side effects, such as libido loss, impotence, and testicular atrophy.
Pharmacology
Oxandrolone exhibits both anabolic and androgenic properties, parallel to testosterone. At lower doses, it selectively promotes muscle growth; however, high doses can lead to significant androgenic effects. High doses may suppress gonadotropin release, subsequently decreasing testosterone synthesis. Like other steroids, Oxandrolone can increase LDL cholesterol while lowering HDL cholesterol, yet it remains one of the few steroids not converted to estrogen.
Indications
While not commonly prescribed today, Oxandrolone was historically used for various anemias, weight management in HIV patients, and even osteoporosis treatment. Following widespread abuse, production ceased in 1989, but Savient Pharmaceuticals now manufactures it as Oxandrin. Physicians may prescribe it to assist critically ill patients in regaining weight post-trauma, burns, or severe infections, sometimes in conjunction with corticosteroids for managing bone pain in cancer patients.
Dosage
For anemia treatment or weight gain, adult doses range from 2.5 to 20 mg per day, divided into 2 to 4 doses. Response varies; some individuals may benefit from as little as 2.5 mg, while others might need 30-150 mg per day over 3-6 weeks. Oxandrin is available in 2.5 mg and 10 mg tablet forms.
Common mild side effects at lower doses may include abdominal discomfort, nausea, or diarrhea. However, high doses can lead to more serious side effects, including:
- jaundice
- liver necrosis
- liver cancer
- general malaise
- testicular atrophy
- hair loss
- breast enlargement
- stomach cramps, nausea, bloating
- acne
- diarrhea
- menstrual irregularities
Most of these side effects are reversible upon discontinuation of the drug.
Contraindications
Oxandrolone should be avoided in patients with:
- suspected prostate cancer
- breast cancer in males or females
- pregnancy
- evidence of hypercalcemia
- an allergy to anabolic steroids
Bodybuilders
Anavar is a staple among bodybuilders due to its rapid absorption when taken with meals. Typical dosing for men is two tablets daily, while women generally take one. Most bodybuilders start at lower doses, often combining Anavar with other compounds like dianabol, winstrol, or anadriol to minimize side effects. Treatment duration commonly lasts 4-8 weeks, beginning with a recommended daily intake of 5 mg, gradually increasing over 2-3 weeks.
Women often favor Anavar for its minimal virilizing effects at lower doses, but exceeding 5 mg daily or persisting beyond 6 weeks can trigger masculinization signs. Weight gain is typically gradual, with noticeable results appearing within 3-4 weeks.
Signs of virilization may include:
- deepening voice
- decreased libido
- clitoral enlargement
- acne
- excessive hair growth
If any virilizing features arise, women are advised to discontinue use immediately. While acne and excessive hair growth may reverse, other symptoms may not.
Warnings
All anabolic steroids carry the risk of liver damage and jaundice. Users have reported liver dysfunction and growths, with liver cancer being the most serious complication. Routine liver function tests and possibly annual ultrasounds are advisable for those using this drug.
Overdose
Anavar is generally safe, and overdose is rare. High doses may lead to discomfort, but are unlikely to be life-threatening. Nevertheless, seeking emergency medical attention is crucial if an overdose occurs, with treatment being supportive.
Costs
Anavar prices for 100 tablets (2.5 mg) range from $100 to $150, although there are widespread issues with counterfeit products. Buyers should obtain supplies from reputable sources. Legitimate Anavar from pharmacies can cost between $700 and $1200 for 100 tablets.
Levels
Anavar and its metabolites are easily detectable in urine. Major sports organizations conduct regular screenings, with such metabolites remaining discernible 7-14 days post-use.
Legal
Anavar is classified as a controlled substance, making its sale and distribution illegal in the USA. The DEA actively oversees its availability, and personal possession is considered a crime, given its lack of clinical use.
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