Oxandrolone – Anavar
Anavar, a mild anabolic steroid, is a favorite among athletes and bodybuilders aiming for weight gain. Its appeal lies in its ability to evade conversion to estrogen, minimizing the risk of gynecomastia and water retention, making it highly sought after in the fitness community. Initially launched nearly half a century ago, Anavar was once prescribed for various infertility disorders and conditions like anemia and muscle wasting in hospitalized patients. Today, its clinical use is rare, with Anavar offering distinct advantages over other anabolic steroids by not converting to estrogen and sparing the hypothalamic-pituitary axis at lower doses. This means users are less likely to experience common side effects like libido loss, impotence, or testicular atrophy.
Pharmacology
Oxandrin exhibits both anabolic and androgenic effects similar to testosterone. At low doses, it selectively promotes anabolism, while higher doses can provoke notable androgenic responses. High dosages may suppress gonadotropin release, potentially leading to decreased testosterone synthesis. Like other anabolic steroids, Oxandrin can elevate LDL cholesterol levels while reducing HDL cholesterol. Notably, Anavar remains one of the rare steroids not converted to estrogen at low doses.
Indications
This medication is infrequently utilized in clinical settings. Historically, it was prescribed for various anemias and weight loss in HIV patients, and trials were conducted for osteoporosis treatment. Following widespread misuse, Searle discontinued production in 1989, with Savient Pharmaceuticals now manufacturing it under the trade name Oxandrin. Occasionally, physicians may prescribe it for critically ill patients recovering from trauma, burns, or severe infections, often in combination with corticosteroids for cancer-related bone pain.
Dosage
For anemia treatment or weight gain in adults, the dosage ranges from 2.5 to 20 mg/day, divided into 2-4 doses. Some may respond to lower doses, while others might need 30-150 mg/day, typically administered over 3-6 weeks. Dosage adjustments occur gradually after an initial response period of 4 weeks. Oxandrin tablets are available in 2.5 mg or 10 mg doses.
While most side effects at lower doses are minor, such as mild abdominal discomfort or nausea, higher doses can lead to serious side effects, including:
- jaundice
- rare hepatic necrosis
- liver cancers
- general malaise
- testicular atrophy
- hair loss
- breast enlargement
- stomach cramps, nausea, bloating
- acne, oily skin
- diarrhea
- menstrual irregularities
- testicular atrophy
Most of these side effects resolve after discontinuation.
Contraindications
Oxandrolone is contraindicated for patients with:
- suspected prostate cancer
- breast cancer (male or female)
- pregnancy
- evidence of hypercalcemia
- allergy to anabolic steroids
Bodybuilders
Bodybuilders often choose Anavar due to its effective absorption when taken with food. Typical male dosing is one tablet twice daily, while females usually take one tablet daily. A gradual increase in dosage over 2-3 weeks is recommended, starting from as low as 5 mg/day. Anavar’s minimal side effects at low doses often lead athletes to stack it with other steroids like dianabol, winstrol, or anadriol. Treatment duration generally ranges from 4-8 weeks.
Women particularly appreciate Anavar for its low virilizing potential; however, doses exceeding 5 mg per day and treatment lengths beyond 6 weeks can lead to muscle masculinization. Weight gain tends to be gradual, with noticeable results typically seen within 3-4 weeks. Signs of virilization include:
- deep voice
- decreased libido
- clitoral enlargement
- acne
- excessive hair growth
Women showing signs of virilization should discontinue use promptly; while some effects like acne may reverse, others may not.
Warnings
All anabolic steroids carry the risk of liver damage and jaundice. Serious complications, including liver cancer, have been documented. Regular monitoring of liver enzymes and annual ultrasounds are advised for those using Anavar.
Overdose
The likelihood of overdose with Anavar is low, and acute effects are not typically life-threatening. However, users experiencing overdose symptoms should seek immediate medical care. Standard treatment for steroid overdose involves supportive care.
Costs
Anavar pricing varies significantly, with 100 tablets (2.5 mg) costing between $100 and $150. Due to its popularity, counterfeit formulations abound. Buyers should secure their supplies from reputable sources, as many do from Mexico, where quality assurance is less guaranteed. Legitimate Anavar from pharmacies typically retails at $700-$1200 for 100 tablets.
Levels
Anavar and its metabolites are detectable in urine, with many sporting organizations routinely screening for anabolic steroids. Residual metabolites can remain in the system for 7-14 days post-dosage.
Legal
Anavar is classified as a controlled substance in the USA, making its sale and distribution illegal. The DEA monitors its distribution in pharmacies and online. Without clinical application in the USA, even personal possession of Anavar is considered a criminal act.
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