Mesterolone – Proviron
Proviron is a unique medication recognized for its anti-estrogenic properties. It operates by inhibiting estrogen receptors in the brain, leading to an increase in Gonadotropins (LH and FSH), which stimulate the testes to enhance testosterone production. Notably, it lacks direct anabolic or androgenic activity.
Originally synthesized in the 1970s, Proviron faded from the market by the late 1990s, with the pharmaceutical company Schering ceasing its manufacture. Many online sellers claiming to offer the product are often untrustworthy, selling either fake versions or contaminated substances. There’s little to no legitimate mass production of this drug. Reports suggest that existing stocks are often smuggled from regions like Asia, Russia, and Mexico, casting doubt on their authenticity.
Initially explored for treating depression and anxiety in both genders, studies eventually pointed to an increase in Gonadotropins and testosterone levels, leading to its consideration in treating fertility issues. However, Proviron is no longer approved for any medical conditions; what is advertised online is usually counterfeit or fake.
Indications
Proviron was once recommended for addressing testosterone deficiency and male infertility linked to issues in the hypothalamus, pituitary, or testes.
Pharmacology
Characterized by its moderate androgenic activity instead of anabolic effects, Proviron is utilized by athletes and bodybuilders to recover from testosterone suppression post use of external anabolic steroids. Unfortunately, many users report dissatisfaction, as it fails to enhance muscle mass or strength, often deemed ineffective. The prevalence of counterfeit products complicates the issue further, making it nearly impossible to ascertain true effectiveness without laboratory testing.
This drug offers anti-estrogen benefits similar to Nolvadex or Arimidex, effectively preventing common side effects of anabolic steroids, such as breast enlargement and water retention. Some claim it contributes to muscle definition; however, the influence of concurrent anabolic steroids can’t be determined. Experienced users have moved towards Nolvadex or Arimidex instead.
Females
Previously, Proviron was also employed by female users. While some report benefits for bodybuilding, numerous others have experienced minimal effects. Given its anti-estrogen properties, women taking this drug should do so under medical supervision.
Dosage
The typical dose of Mesterolone is 25 mg taken orally 2-3 times daily for a few months, followed by a maintenance phase. It is rapidly absorbed into the bloodstream, boasting a half-life ranging from 12-24 hours, causing it to remain detectable in urine for at least two weeks post last dose. Due to its limited efficacy as an anti-estrogen, it is frequently combined with Tamoxifen or Arimidex, particularly during the washout phase.
Side Effects
As with any medication, Proviron may lead to infrequent but concerning side effects, which can include:
- painful erections
- loss of libido
- general fatigue
- deepening voice
- excessive hair growth
- acne and oily skin
Contraindications
Proviron is discouraged for use by:
- children
- pregnant women
- individuals with liver dysfunction
- those diagnosed with prostate cancer
- individuals with allergies
Cost
When obtainable, Proviron is costly, with quality and purity often questioned. Most Proviron currently available is sourced from the black market, primarily smuggled from Mexico and the East, with a 20 mg pill costing around $3-$4, making authenticity unverifiable.
Detection
As a banned substance in many sporting organizations, Proviron is routinely screened in urine tests. Due to its prolonged half-life, it can be detected up to two weeks after administration.
Legal
While possession of Proviron is not illegal, its detection is common in sports drug testing protocols. In the USA, it falls under the Controlled Substances Act as a Schedule III drug.
Final Word
Proviron has become a relic of the past, with authentic products no longer available. What’s on the market is likely fake or compromised. For those committed to enhancing their physique, alternatives like Arimidex offer superior efficacy.
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