Mesterolone – Proviron
Proviron is a unique drug with anti-estrogenic effects. By inhibiting estrogen receptors in the brain, it stimulates the release of gonadotropins (LH and FSH), prompting the testes to produce more testosterone. It is important to note that Proviron does not have significant anabolic or androgenic properties.
Originally synthesized in the 1970s, Proviron faded from the market by the late 1990s. Its manufacturer, Schering, has ceased production, leading to a proliferation of counterfeit products online. Most sellers claiming to offer Proviron may be distributing fake drugs, as there is no mass manufacturing currently taking place. Authenticity is questionable, particularly with reports of smuggling from Asia, Russia, and Mexico.
This medication was tested for treating depression and anxiety in both men and women, revealing an increase in gonadotropins and testosterone levels, which led to its proposed use in addressing fertility issues. However, today, Proviron is obsolete for any medical treatment, and the products available online are likely not genuine.
Indications
Once used to manage testosterone deficiency and male infertility caused by issues with the hypothalamus, pituitary gland, or testes, Proviron is no longer recognized for these indications.
Pharmacology
Proviron is known for its mild androgenic activity rather than anabolic effects and has been utilized by athletes and bodybuilders to recover from testosterone suppression following exogenous steroid use. Many bodybuilders have expressed disappointment with Proviron, reporting minimal muscle mass or strength gains, mainly due to widespread counterfeit versions of the drug. Testing in a chemistry laboratory is essential to ascertain the integrity of the product purchased.
Similar to drugs like Nolvadex or Arimidex, Proviron exhibits anti-estrogen properties, helping alleviate side effects such as breast enlargement and water retention associated with anabolic steroids. While some users report a muscle “bulge” effect, attributing it solely to Proviron is difficult due to concurrent usage of various anabolic substances. Most knowledgeable athletes now prefer Arimidex or Nolvadex over Proviron.
Females have also utilized Proviron in the past, but mixed reports of efficacy exist. Its anti-estrogen properties mean that female users should be monitored by healthcare professionals during use.
Dosage
The recommended dose for Mesterolone is typically 25 mg taken orally 2-3 times daily for several months, followed by a maintenance phase. Proviron is quickly absorbed into the bloodstream with a long half-life of 12-24 hours, remaining detectable in urine for at least two weeks after the last dose. Due to its limited effectiveness as an anti-estrogen, it is often combined with Tamoxifen or Arimidex during washout phases.
Side Effects
As with any medication, Proviron can cause rare and occasionally unsettling side effects, which may include:
- painful erections
- loss of libido
- general fatigue
- deepening of voice
- increased hair growth
- acne and oily skin
Contraindications
Use of Proviron is not recommended in:
- children
- pregnant females
- individuals with liver dysfunction
- those with prostate cancer
- individuals with allergies
Cost
When available, Proviron is known to be costly and its quality remains questionable. Mostly acquired on the black market, it is reportedly smuggled into the U.S. from Mexico and the Far East. Prices for 20 mg pills range from $3 to $4, with the risk of counterfeit products being high.
Detection
As a banned substance in many sports, Proviron is routinely tested for in urine samples, remaining detectable for up to two weeks due to its long half-life.
Legal
Possession of Proviron is not illegal; however, it is monitored by sporting organizations. In the USA, Proviron is classified as a Schedule 3 controlled substance.
Final Word
Proviron has effectively become a relic of the past, with authentic products no longer available. The current market is flooded with likely fake or contaminated substances. For those seeking to enhance their physique, alternatives like Arimidex offer more reliable solutions.
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