Testosterone Suspension
For beginners, the term testosterone suspension might be confusing as there isn’t a specific drug labeled as such. Testosterone, a large molecule, is insoluble in water, necessitating its dissolution in various oils for injectable formulations.
By modifying the side chains of the steroid, absorption rates and action duration are enhanced. These formulations include esters like propionate, acetate, and decanoate. When mixed with sesame seed oil, they form a suspension.
Esterification is crucial for enhancing testosterone solubility in oil, leading to a controlled release into the bloodstream upon injection. Testosterone suspensions must be administered intramuscularly, not orally, for effective absorption.
Different suspensions vary in absorption rates, but daily injections are unnecessary; most can remain as a depot in the muscles for several days to a week. Testosterone, also known as tesamone, serves as an oily suspension with similar actions to other testosterone products, functioning as both an anabolic and androgenic agent. Various types are available in the USA, available solely via a prescription from a physician.
Testosterone suspensions are indicated for conditions related to testosterone deficiency or issues with gonadotropin release. They are prescribed for:
- infertility
- delayed puberty
- women with advanced breast cancer
- promoting growth in malnourished individuals
Pharmacology
Testosterone plays a vital role in the development of male sex organs and secondary sexual characteristics. The hormone influences the growth of the prostate, testis, seminal vesicles, penis, scrotum, and overall body size. Despite its androgenic nature, testosterone also possesses anabolic properties, promoting protein synthesis and creating a positive nitrogen balance in a calorie-rich diet.
Additionally, testosterone mildly raises red blood cell production by stimulating erythropoietin synthesis from the kidneys, enhancing oxygen delivery throughout the body.
Prolonged use of testosterone can inhibit gonadotropin release via a negative feedback mechanism from the pituitary gland, and in high doses, it may suppress spermatogenesis.
Dosage
All testosterone suspensions are delivered intramuscularly, typically remaining active in the body for 48-72 hours. However, the esterification process increases the duration of detectable testosterone in urine. Users often report injection discomfort in the buttocks, possibly due to large volumes or abscess formation; thus, it’s advisable to use small volumes and rotate injection sites.
Recommended dosages for novice bodybuilders start at approximately 25 mg weekly, with some users opting for 50-100 mg/week. Others may mix different testosterone formulations. The treatment period should be limited to 4-6 weeks to allow for recovery of the hypothalamic-pituitary axis. During the washout phase, many athletes utilize Nolvadex (tamoxifen) to counteract estrogenic side effects.
Always inspect vials before injection; if fine crystals persist after shaking, do not use the product. As with all testosterone products, suspensions inhibit natural testosterone synthesis in the testes and affect the hypothalamic-pituitary axis, thus requiring careful tapering instead of abrupt cessation.
Duration
Testosterone suspension treatment length varies by age, gender, diagnosis, response to treatment, and side effects onset. Injections should be limited to the buttock muscles, avoiding subcutaneous administration and rotating sites to prevent abscesses. It’s also acceptable to inject into the outer thigh, but intravenous administration is prohibited.
The monthly dosage shouldn’t exceed 200-1000 mg due to potential side effects. Verify the product’s clarity before injection; any color changes or particulates signify expiry or inactivation. Standard treatment spans 1-2 months, with storage at room temperature.
Bodybuilders
Many bodybuilders utilize testosterone suspensions during the off-season due to their prolonged effects, advising against use during active competition. The anabolic and androgenic properties of testosterone manifest gradually, typically requiring 3-4 weeks for noticeable results. Combinations with other anabolic hormones like GH/thyroxin are common.
Since testosterone converts to estrogen in fatty tissues, some users may experience breast enlargement and water retention. Typical dosages for muscle gain range from 250 to 1000 mg/week, but higher doses risk significant side effects, making gradual increases advisable for beginners.
While protein mass increase is gradual, the stimulation of red blood cell production improves exercise performance under strain. Bodybuilders favor different formulations based on availability and vendor trustworthiness, citing the drug’s benefits in health, performance, and nitrogen balance improvement. Dramatic water retention may necessitate diuretic usage.
To mitigate breast enlargement, many cycle testosterone with Arimidex or Tamoxifen, generally using it for 4-6 weeks followed by a washout phase during which Arimidex might be implemented.
Side effects include:
- irregular menstrual cycles
- virilizing effects
- deepening voice
- clitoral enlargement
- gynecomastia
- painful penile erections
- hair loss, acne, oily skin
- water retention
- nausea, vomiting, jaundice
- rare liver cancer
- mental changes – anger, depression, headaches, anxiety
- elevated serum cholesterol
While many side effects are reversible, breast enlargement and some virilizing effects might not be. Concurrent estrogen use to diminish virilization effects is not consistently effective.
Women
All testosterone analogues carry the risk of virilizing effects with prolonged use in females, potentially leading to deepening voice, excessive hair growth, menstrual irregularities, mood changes, and clitoral enlargement. It’s crucial to halt the drug at any early sign of virilization, as some effects may not reverse even after cessation.
Warnings
Use testosterone cautiously in individuals with:
- breast cancer and hypercalcemia
- liver disorders
- heart conditions
Isolated reports suggest that some individuals may experience dry cough or breathing issues post-injection, possibly attributable to oil-based formulations or contaminants.
Regularly check liver enzymes and blood hematocrit for safety compliance.
Overdose
Overdose of tesamone is rare; while high doses can be injected, acute life-threatening effects are unlikely. Nevertheless, users may feel unwell for weeks until the drug clears, and seeking medical attention is advisable.
Anyone using anabolic steroids should maintain regular consultations with healthcare professionals to monitor liver enzymes and hematocrit levels.
Legal
Classified as a Schedule III drug under the Controlled Substances Act, testosterone is available exclusively via prescription. Physicians often hesitate to prescribe steroids.
Detection
Testosterone suspensions can remain detectable in the body for extended periods. Current testing methods can identify testosterone or its metabolites in urine for 3-4 weeks post-use. In fact, traces can even be found in hair follicles 2-4 months after discontinuation, particularly if excessive use is suspected.
It’s important to note that current detection methods are imperfect, with approximately 50% of users not flagged due to testosterone/epitestosterone ratios.
Cost
Legal testosterone suspensions are often hard to obtain; most bodybuilders resort to black market sources. Generic formulations produced in Europe and Mexico are widely accessible, typically costing between $10-$40 per 250 mg vial. Over the past 20 years, increased regulation by the DEA has led to counterfeit products flooding the market, emphasizing the need for caution in purchasing.
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