Testosterone Undecanoate
Is a long-acting testosterone formulation designed for individuals with absent or significantly low hormone levels. Unlike other testosterone esters, it is available as an oral pill, although an injectable version is accessible in Europe. The unique undecanoate structure allows testosterone to bypass liver metabolism. In North America, only the oral pill is found through black market avenues. Despite its innovative oil formulation, many bodybuilders report minimal effects, often seeing no significant response.
Pharmacology
The body produces sex hormones, including testosterone, vital for the normal growth and development of secondary sexual traits, such as:
- Prostate and testes development
- Body hair growth
- Vocal cord thickening
- Body fat and muscle alterations
Deficiencies in testosterone result in abnormal secondary sexual characteristics and hindered growth, bringing about the need for testosterone therapy in those lacking this essential hormone.
Indications for Use
Testosterone undecanoate is prescribed for conditions where testosterone secretion fails, including:
- Primary testicular failure
- Inadequate pituitary gonadotropin release
Bodybuilding
Athletes and bodybuilders frequently use testosterone and its analogs to enhance performance and stimulate mental well-being. However, many users report minimal benefits beyond slight weight gain, often making it difficult to attribute results to a single substance. Testosterone exhibits moderate anabolic properties while being a potent androgenic agent.
Common oral doses range from 25-200 mg/day, with effects often minimal even at 400 mg/day. Prolonged use (4-6 weeks) may yield minor increases in body mass and protein synthesis, contingent on a calorie-rich diet. Additionally, many bodybuilders use a combination of various hormones concurrently, risking estrogen conversion in fatty tissues, which could lead to gynecomastia and water retention. To mitigate these side effects, substances like Arimidex or tamoxifen are commonly added during off cycles.
Furthermore, testosterone intake suppresses natural testosterone production through feedback inhibition, possibly impairing spermatogenesis. A gradual tapering is advised to recover the hypothalamic-pituitary axis and prevent withdrawal symptoms such as fatigue, weight loss, and increased fracture risk.
Contraindications
Certain individuals should refrain from using testosterone due to potential exacerbation of existing conditions, including:
- Allergies to the drug
- Male breast or prostate cancer
- Pregnant or breastfeeding women
- Those with liver, kidney, or heart issues
Side Effects
Possible adverse reactions to testosterone undecanoate include:
- Nausea and vomiting
- Abdominal cramps and diarrhea
- Swelling
- Libido changes
- Headaches
- Acne and oily skin
- Mood changes such as anger and depression
- Excessive sweating
- Hair loss
- Gynecomastia
In females, virilizing effects can occur, such as:
- Deepened voice
- Hoarseness
- Excess hair growth
- Enlarged clitoris
- Irregular menstrual cycles
Testosterone undecanoate can convert to estrogen in fat, leading to breast enlargement and water retention, typically after 4 weeks of usage. Gynecomastia may reverse upon discontinuation.
Overdose
Although rare, overdose on testosterone undecanoate can occur; doses as high as 400-600 mg/day may produce minimal acute effects. Most people will experience little to no symptoms, while some may report diarrhea or cramps. Seeking medical attention is advisable based on individual dose intake.
Dosage
In clinical settings, testosterone undecanoate is not commonly utilized, despite the availability of oral and injectable forms in Europe. The injectable version is administered intramuscularly and is available as 40 mg pills or 250 mg/ml injections given every 7-12 days. Most testosterone remains protein-bound, with only 2% free. The oral pill should be administered daily, whereas injections may be done weekly, though some bodybuilders opt for bi-daily injections, which is discouraged as it may cause abscesses or skin issues.
It’s vital to rotate injection sites for ongoing treatments and avoid injecting into arms or abdomen. Many bodybuilders typically use higher dosages of 200-400 mg/week, with gradual absorption into the bloodstream over subsequent days.
Control
Testosterone undecanoate is classified as a controlled substance under class 3 per the controlled substance act; it’s illegal in the USA. Possessing, distributing, or selling this anabolic steroid is prohibited.
Detection
Excretion of testosterone undecanoate and its metabolites can be detected in urine for 2-3 weeks post-injection. Due to its prolonged detection window, many bodybuilders prefer using it during off-seasons.
Availability
The majority of bodybuilders acquire testosterone undecanoate from black market sources. In the USA, it’s solely obtainable illegally. Generic versions exist from manufacturers in Europe, Japan, Mexico, Spain, Brazil, and Thailand, though product quality and authenticity are often questionable.
Most bodybuilders use 50-400 mg/day, with costs averaging $60-$100 for 50 pills (40 mg each). However, concerns persist regarding product purity, and counterfeit products are rampant.
Final Word
Andriol should be the last resort for bodybuilders due to its scarcity, ineffectiveness, and high cost—alongside the risk of counterfeit purchases.
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