Sildenafil
Sildenafil, a member of the phosphodiesterase type 5 (PDE5) inhibitors class, is commonly known by its brand name, Viagra.
Key characteristics of sildenafil:
Mechanism of Action
- Sildenafil effectively inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP). Increased levels of cGMP, stimulated by nitric oxide (NO) during sexual arousal, lead to the relaxation of smooth muscle in blood vessels, enhancing blood flow to the penis.
- This mechanism facilitates both the achievement and maintenance of an erection.
Indications
- Sildenafil is primarily indicated for the treatment of erectile dysfunction in men.
- Additionally, it may be utilized for managing arterial hypertension under the trade name Revatio.
Onset of Action
- The onset of action for sildenafil is notably quick, typically commencing around 30 minutes post-ingestion, although it may take up to 1 hour in some users.
Duration of Action
- The effects generally persist for 4 to 5 hours, sufficient for achieving and sustaining an erection.
Dosage
- The standard initial dose of sildenafil is 50 mg; adjustments can be made based on individual response and requirements.
- The recommended timing for dosage is approximately 30 minutes to 1 hour prior to anticipated sexual activity.
Side Effects
- Common side effects include headache, facial flushing, indigestion (such as nausea and diarrhea), vision disturbances (including blurred vision and alterations in color perception), elevated blood pressure, and in rare cases, hearing loss or changes in hearing capability.
Contraindications
- Use of sildenafil with nitrates (e.g., nitroglycerin) is contraindicated due to the risk of significant hypotension. It is also not recommended for individuals with severe cardiovascular issues, recent myocardial infarction, or stroke.
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