Mesterolone – Proviron
Proviron, known for its anti-estrogenic properties, blocks estrogen receptors in the brain, triggering a release of gonadotropins (LH and FSH) that stimulate the testes to produce more testosterone. However, it lacks direct anabolic or androgenic activity. Initially synthesized in the 1970s, Proviron was discontinued by Schering in the late 90s, leading to concerns over the authenticity of products sold online—most are likely counterfeit. Proviron was formerly considered for treating depression and anxiety, revealing potential in increasing gonadotropins and testosterone, which later led to its use for addressing fertility issues. Despite this, it’s now obsolete for medical treatment, with online offerings generally deemed untrustworthy.
Indications
Previously, Proviron was prescribed for testosterone deficiency and male fertility challenges linked to hypothalamic, pituitary, or testicular issues.
Pharmacology
With more pronounced androgenic than anabolic effects, Proviron helps athletes rebound from testosterone suppression caused by prolonged anabolic steroid use. Many bodybuilders have reported dissatisfaction, noting minimal gains in muscle mass or strength. This discontent is often attributed to the prevalence of fake Proviron, as only rigorous lab testing can confirm product integrity. Serving as an anti-estrogen like Nolvadex or Arimidex, it mitigates breast enlargement and water retention, common side effects of anabolic steroids. While some users claim enhanced muscle definition, this is challenging to attribute solely to Proviron given the concurrent use of other steroids. Most experienced athletes have shifted toward Arimidex or Nolvadex instead.
Females
Female users of Proviron have also shared mixed results regarding its supposed bodybuilding advantages. Due to its anti-estrogen activity, medical supervision is advised for any female taking this drug.
Dosage
The recommended dose of Mesterolone is 25 mg taken orally 2-3 times daily for several months, followed by maintenance therapy. Proviron is rapidly absorbed, boasting a long half-life of 12-24 hours and can be detected in urine for at least 2 weeks post-administration. Frequently paired with Tamoxifen or Arimidex, it is typically utilized during the washout phase.
Side Effects
Like any medication, Proviron can cause rare but concerning side effects, which may include:
- painful erections
- loss of libido
- general fatigue
- deepening of voice
- hair growth
- acne and oily skin
Contraindications
Proviron is not advisable for use in:
- children
- pregnant women
- those with impaired liver function
- individuals with prostate cancer
- people with allergies
Cost
When available, Proviron is costly, and quality is often questionable. Most Proviron is obtained through black-market channels, predominantly smuggled from Mexico and the Far East, with a 20 mg pill costing $3-$4 and often being fraudulent.
Detection
Proviron is classified as a banned substance by most sports organizations and is actively monitored in urine tests. Due to its prolonged half-life, it can remain detectable for up to 2 weeks post-dose.
Legal
Possession of Proviron is legal; however, it’s banned in most sports due to screening practices. In the USA, it is categorized under the Controlled Substances Act as a Schedule 3 drug.
Final Word
Proviron has become a relic of the past. Genuine products are virtually nonexistent, and current offerings are often fake or contaminated. For those aspiring to enhance their physiques, alternatives like Arimidex prove to be superior options.
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