Mesterolone – Proviron
Proviron, known scientifically as Mesterolone, is a unique compound featuring strong anti-estrogenic properties. By inhibiting estrogen receptors in the brain, it facilitates a significant increase in gonadotropins (LH and FSH), subsequently prompting the testes to enhance testosterone production. Notably, Proviron lacks any inherent anabolic or androgenic activity.
Originally synthesized in the 1970s, it vanished from the market by the late 1990s, with Schering Pharmaceuticals discontinuing its production. With currently no legitimate mass production of Proviron, online sellers claiming to offer it are often peddling counterfeit products. Reports indicate that the drug may be smuggled from regions such as Asia, Russia, and Mexico, casting doubt on its authenticity.
Initially explored for treating depression and anxiety in both genders, research revealed that Proviron could elevate gonadotropin levels and testosterone. However, it has since fallen out of use in medical practice, and virtually all products encountered online are likely fraudulent.
Indications
Previously, Proviron was prescribed for addressing testosterone deficiency and male infertility issues stemming from hypothalamic, pituitary, or testicular dysfunction.
Pharmacology
Proviron exhibits more androgenic than anabolic qualities. It has been utilized by athletes and bodybuilders primarily to combat testosterone suppression following the extended use of anabolic steroids. However, many bodybuilders have expressed disappointment, claiming it does not significantly boost muscle mass or strength. The scarcity of authentic Proviron may contribute to such dissatisfaction, compounded by substantial instances of counterfeit products in circulation. To ascertain authenticity, laboratory testing is essential.
Nonetheless, Proviron’s anti-estrogen properties rival those of Nolvadex or Arimidex, helping mitigate common side effects of anabolic steroids, such as breast enlargement and water retention. Some users report enhanced muscle definition, but this is often associated with their concurrent use of other steroids, complicating the attribution of muscle growth to Proviron alone. Consequently, knowledgeable athletes have largely shifted to alternatives like Arimidex or Nolvadex for these effects.
Females
In the past, Proviron was occasionally employed by female bodybuilders; however, results are mixed, with many reporting minimal effectiveness. Due to its anti-estrogen activity, it is crucial for female users to be monitored by qualified health professionals.
Dosage
The suggested dosage of Mesterolone is 25 mg administered orally 2-3 times daily over several months, followed by a maintenance regimen. When taken orally, Proviron achieves rapid absorption and boasts a long half-life of approximately 12-24 hours, remaining detectable in urine for at least two weeks post-administration. Often, it is combined with Tamoxifen or Arimidex during the washout period.
Side Effects
Like any medication, Proviron can entail rare yet concerning side effects, which may include:
- painful erections
- loss of libido
- general fatigue
- deepening voice
- excess hair growth
- acne and oily skin
Contraindications
Proviron is contraindicated in:
- children
- pregnant individuals
- those with impaired liver function
- individuals diagnosed with prostate cancer
- people with known allergies
Cost
When available, Proviron can be notably expensive, often acquired through black-market channels. Typically imported from Mexico and the Far East, one 20 mg tablet can cost between $3-$4, with no guarantee of authenticity.
Detection
As a banned substance in most sports, Proviron undergoes routine urine screening. Its extended half-life allows for detection up to two weeks after the last dose.
Legal
While possessing Proviron is not illegal, it is classified as a Schedule III controlled substance under the USA’s Controlled Substance Act, complicating its legal status in competitive sports.
Final Word
Proviron now resides in the annals of pharmaceutical history. The genuine product is no longer accessible; what remains on the market is likely counterfeit or contaminated. For those aspiring to enhance physical performance, alternatives like Arimidex present far better options.
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