Exemestane (Aromasin)
Known predominantly as Aromasin, Exemestane is an active substance with other potential brand names. This SERM medication is primarily used to combat breast cancer but has gained considerable traction among steroid enthusiasts for managing estrogenic side effects associated with aromatizable steroids.
As a member of the anti-estrogen class, Exemestane functions as an Aromatase Inhibitor (AI), similar to Anastrozole (Arimidex) and others. It’s crucial to understand that there are two categories of anti-estrogens: AIs and Selective Estrogen Receptor Modulators (SERMs), like Nolvadex (Tamoxifen) and Clomid (Clomiphene). Both AIs and SERMs address estrogen-related issues but differ significantly in their mechanisms and effectiveness.
Typically, Aromatase Inhibitors obstruct estrogen synthesis by inhibiting the aromatase enzyme, leading to reduced estrogen levels. This makes Exemestane particularly effective for slowing the progression of estrogen-dependent breast cancers and alleviating side effects in steroid users aiming for enhanced physique and performance.
Approved by the FDA in 1999, Aromasin quickly gained popularity worldwide, recognized for its efficiency in lowering estrogen levels.
Half-Life
Research indicates that the half-life of Exemestane ranges from 24 to 27 hours, meaning that it takes approximately that time for half of the dosage to leave the system. Consequently, it typically clears from the body within 48 to 54 hours. Keep in mind that detection times may extend significantly longer, particularly during anti-doping tests, potentially lasting up to two weeks.
What is Exemestane Used For?
As mentioned, Exemestane, or Aromasin, plays a pivotal role in reducing estrogen levels, which can have numerous beneficial effects. Elevated estrogen can lead to various adverse outcomes, similar to any excess in the body. By lowering estrogen, steroid users gain estrogenic protection while women facing hormone-positive breast cancer can slow tumor growth.
Aromasin is classified as a suicidal aromatase inhibitor, permanently deactivating aromatase upon binding—unlike some AIs such as Arimidex and Letrozole, which may lead to “estrogen rebound” upon cessation. Studies demonstrate that Aromasin can reduce estrogen levels by up to 85%, showcasing its long-lasting effects compared to other AIs.
This compound is particularly beneficial for steroid users taking aromatizing anabolic steroids like Dianabol, Nandrolones, and Testosterone. Elevated estrogen can result in unwanted side effects, such as gynecomastia, water retention, and hypertension. Exemestane effectively manages these issues by lowering estrogen levels.
Dosage
Considering the half-life of approximately 25-27 hours, daily intake is recommended to maintain stable blood levels of Exemestane. Some users may find every other day dosing sufficient to avoid excessive estrogen suppression, tailoring their dosage based on individual needs and the steroids’ characteristics.
Typical dosages range from 12.5 mg every other day to 25 mg daily. It’s crucial to avoid exceeding recommended dosages, as excessive suppression of estrogen can lead to its own adverse effects.
Side Effects
While Exemestane is generally well-tolerated at recommended doses, excessive use can lead to dangerously low estrogen levels. Adverse effects associated with low estrogen may include:
- Depression
- Insomnia and low libido
- Impotence
- Low energy
Abusing Aromasin is not advised; it should be employed judiciously. Side effects are rare among bodybuilders who typically use it at proper doses for brief periods, while women requiring prolonged treatment may face increased risks. Common side effects may include sweating, insomnia, headaches, hot flashes, and joint pain, often alleviated by adjusting the dosage.
Ultimately, not using an aromatase inhibitor when utilizing aromatizable steroids significantly increases the likelihood of experiencing negative side effects compared to using appropriate estrogenic protection.
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