Mesterolone – Proviron
Proviron is an anti-estrogenic medication that operates by obstructing estrogen receptors within the brain, leading to an elevation in Gonadotropins (LH and FSH) which stimulate the testes to enhance testosterone production. Despite its hormonal influence, it lacks direct anabolic or androgenic properties.
Originally synthesized in the 1970s, Proviron faded from the market by the late 1990s and is no longer manufactured by Schering. Consequently, online vendors claiming to offer genuine Proviron are likely either dishonest or distributing counterfeit goods, with no mass production currently taking place. Instances of smuggling from Asia, Russia, and Mexico have arisen, casting doubt on the authenticity of any available product.
Initially explored as a treatment for both male and female patients experiencing depression and anxiety, further research revealed its potential to increase Gonadotropins and testosterone levels, thus paving the way for its use in addressing fertility issues. However, Proviron is now obsolete for medical treatments, with the consensus being that online procurements are likely forgeries.
Indications
Historically, Proviron was indicated for male testosterone deficiency and infertility linked to hypothalamic, pituitary, or testicular disorders.
Pharmacology
Proviron exhibits more androgenic attributes than anabolic effects, often utilized by athletes and bodybuilders to counteract testosterone suppression resulting from extended use of anabolic steroids. Unfortunately, many bodybuilders have expressed dissatisfaction, claiming it fails to enhance muscle mass or strength and often labeling it ineffective, primarily due to the prevalence of counterfeit products. Authenticity can only be confirmed through laboratory testing.
This drug also shares anti-estrogen qualities similar to Nolvadex or Arimidex, effectively preventing common steroid-related side effects such as breast enlargement and water retention. Some users report a bulging and ripped appearance; however, the combined use of multiple anabolic steroids complicates the attribution of these effects solely to Proviron. Its conventional role during washout cycles to maintain testosterone levels has led many informed athletes to prefer Arimidex or Nolvadex instead.
Females have also utilized Proviron, yet reports on its effectiveness vary, necessitating medical oversight due to its anti-estrogen effects.
Dosage
The typical dosage of Mesterolone is 25 mg taken orally 2-3 times daily over several months, followed by maintenance therapy. It showcases rapid absorption with a prolonged half-life of approximately 12-24 hours, remaining detectable in urine for at least two weeks post-administration. Due to its limited anti-estrogen effectiveness, it is frequently combined with Tamoxifen or Arimidex, particularly during washout periods.
Side Effects
Like all medications, Proviron carries potential side effects, albeit rare. Commonly reported issues include:
- painful erections
- libido loss
- fatigue
- voice deepening
- excessive hair growth
- acne and oily skin
Contraindications
Proviron is advised against in:
- children
- pregnant women
- individuals with liver dysfunction
- those with prostate cancer
- individuals with allergies
Cost
When available, Proviron can be pricey, with quality and purity hanging in the balance. Currently, it is predominantly found on the black market, often smuggled into the U.S. from Mexico and Asia, priced around $3-$4 per 20 mg pill, and there’s no assurance of authenticity.
Detection
Proviron is prohibited by numerous sports organizations and is detectable in urine for up to two weeks due to its long half-life.
Legal
Possession of Proviron is not illegal; however, all sports agencies routinely screen for it, and in the U.S., it falls under the controlled substance act as a Schedule 3 drug.
Final Word
Proviron has become a relic of history, with genuine products no longer available. Current offerings are most likely counterfeit or tainted. For those seeking to enhance their physique, Arimidex presents a far superior alternative.
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