Oxandrolone – Anavar
Anavar is a renowned, mild anabolic steroid widely favored among athletes and bodybuilders for its ability to facilitate weight gain. Its popularity stems from its unique profile, as it does not convert to estrogen, significantly reducing the risk of gynecomastia and water retention.
Launched nearly 50 years ago in North America, Anavar was initially utilized for treating infertility, anemia, and severe weight loss in hospitalized patients. Today, its clinical application is limited, but it boasts two significant advantages: no estrogen conversion and minimal impact on the hypothalamic-pituitary axis at low doses. This means that those using Anavar are less likely to experience common side effects associated with other anabolic steroids, such as loss of libido, impotence, or testicular atrophy.
Pharmacology
Oxandrin displays anabolic and androgenic properties, showing similar actions to testosterone. At lower dosages, it exerts selective anabolic effects, whereas higher doses can evoke potent androgenic activity. At elevated dosages, it may suppress gonadotropin release from the hypothalamus, leading to diminished testosterone synthesis. Like many anabolic steroids, Oxandrin increases levels of LDL cholesterol while reducing HDL cholesterol. Remarkably, Anavar remains unaffected by estrogen conversion at lower doses.
Indications
This drug’s clinical use is scarce. Historically, it treated anemia, weight loss in HIV patients, and was even trialed for osteoporosis. Due to abuse concerns, Searle ceased production in 1989. Currently manufactured by Savient Pharmaceuticals under the name Oxandrin, some physicians prescribe it for moribund patients to aid recovery post-trauma, burns, or severe infections, occasionally in conjunction with corticosteroids for alleviating bone pain in cancer patients.
Dosage
For anemia and weight gain support, the typical adult dose ranges from 2.5 to 20 mg/day, divided into 2-4 doses. Individual response varies, with some observing results at lower doses while others may require 30-150 mg/day. Treatment duration is generally between 3-6 weeks, with a gradual increase if no improvement is noted within the first 4 weeks. Oxandrin is available as tablets in 2.5 mg or 10 mg options.
As with all anabolic steroids, Oxandrin can manifest side effects. At low dosages, effects are often mild, such as abdominal discomfort or nausea. However, higher doses may present:
- jaundice
- rare hepatic necrosis
- liver cancer
- general malaise
- testicular atrophy
- hair loss
- breast enlargement
- stomach cramps
- acne and oily skin
- diarrhea
- menstrual irregularities
Most side effects are reversible upon discontinuation.
Contraindications
Oxandrolone should be avoided in patients with:
- suspected prostate cancer
- breast cancer (male or female)
- pregnancy
- evidence of hypercalcemia
- anabolic steroid allergies
Bodybuilders
Bodybuilders frequently choose Anavar due to its quick absorption when ingested with meals. Typical dosing is one tablet twice daily for men and one tablet daily for women. Most bodybuilders initiate treatment at lower doses, often combining Anavar with other compounds like dianabol, winstrol, or anadrol to minimize side effects. Treatment duration may range from 4-8 weeks, with an initial recommendation of 5 mg/day and gradual increases over 2-3 weeks.
Anavar is especially appealing to women due to low virilization risk at recommended doses. However, doses exceeding 5 mg/day or extending beyond 6 weeks may result in masculinizing signs, with weight gains slow and noticeable after 3-4 weeks.
Signs of virilization include:
- deep voice
- decreased libido
- clitoral enlargement
- acne
- excess hair growth
Women showing virilization symptoms should discontinue use immediately. While acne and hair growth may resolve, other virilizing signs can be permanent.
Warnings
All anabolic steroids pose risks of liver damage and jaundice. Instances of liver dysfunction and growths are documented, with liver cancer as the most severe complication. Users should monitor liver enzymes regularly and consider yearly ultrasounds.
Overdose
Generally, anabolic steroids are safe, with overdose being unlikely. However, excessive intake can lead to discomfort, and a visit to the emergency room is advised in such cases. Supportive care is the recommended treatment for steroid overdose.
Costs
Prices for Anavar (100 tablets of 2.5 mg) range from $100-$150. Due to high demand, counterfeit products are prevalent, so sourcing from reputable dealers is crucial. Some bodybuilders resort to Mexican suppliers, but quality and purity are not guaranteed. Genuine Anavar sold through pharmacies can range from $700-$1200 for 100 tablets.
Levels
Anavar and its metabolites are easily detectable in urine tests, with many sports organizations routinely screening for anabolic steroids. Metabolite traces can remain in the system for 7-14 days post-final dosage.
Legal
As a controlled substance, the sale and distribution of Anavar are prohibited in the USA. The DEA monitors its availability in pharmacies and online. Given its non-clinical status, personal possession in the USA is illegal.
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