Tadalafil – Cialis
Tadalafil is a powerful medication classified as a phosphodiesterase type 5 (PDE5) inhibitor, primarily recognized under the brand name Cialis for erectile dysfunction and as Adcirca for addressing pulmonary arterial hypertension.
Mechanism of Action
- Tadalafil effectively inhibits the enzyme phosphodiesterase type 5 (PDE5), preventing the breakdown of cyclic guanosine monophosphate (cGMP).
- Upon sexual arousal, nitric oxide (NO) is released, escalating cGMP levels.
- This process promotes relaxation of the smooth muscle in blood vessels, enhancing blood flow to the penis and facilitating an erection.
Indications
- Primarily prescribed for erectile dysfunction in men.
- Also utilized for managing benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension as Adcirca.
Onset of Action
- Tadalafil typically begins to take effect within 30 minutes to 1 hour.
Duration of Action
- The effects can persist for up to 36 hours, earning it the nickname “weekend pill.”
- Men can maintain an erection throughout this duration when sexually stimulated.
Dosage
- The recommended dose for treating erectile dysfunction is 10 mg or 20 mg, taken as needed about 30 minutes before sexual activity.
- For BPH management, a daily dose of 5 mg is common.
Side Effects
- Typical side effects may include headache, facial flushing, indigestion (e.g., nausea, diarrhea), dizziness, muscle aches, and back pain.
- Serious side effects like sudden vision or hearing loss are rare but possible.
Contraindications
- Should not be combined with nitrates (e.g., nitroglycerin) due to the risk of significant blood pressure drops.
- Contraindicated in individuals with severe heart conditions, recent heart attack, or stroke.
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