Sildenafil
Sildenafil, marketed under the brand name Viagra, is a renowned medication classified as a phosphodiesterase type 5 (PDE5) inhibitor.
Characteristics of sildenafil
Mechanism of Action
- Sildenafil inhibits the enzyme PDE5, preventing the breakdown of cyclic guanosine monophosphate (cGMP). This action enhances sexual stimulation by allowing increased levels of cGMP, relaxing smooth muscles and promoting blood flow to the penis, facilitating an erection.
- This mechanism enables the achievement and maintenance of an erection.
Indications
- Primarily prescribed for the treatment of erectile dysfunction in men.
- Also indicated for treating arterial hypertension under the name Revatio.
Onset of Action
- Sildenafil typically begins to work within 30 minutes, though onset may extend to 1 hour for some individuals.
Duration of Action
- The effects can last from 4 to 5 hours, providing a suitable window for achieving and maintaining erections.
Dosage
- The standard initial dose is 50 mg, adjustable based on individual response and needs.
- To optimize effect, take approximately 30 minutes to 1 hour before sexual activity.
Side Effects
- Commonly reported side effects include headache, facial flushing, indigestion (nausea and diarrhea), vision changes (blurred vision, color perception), increased blood pressure, and in rare cases, hearing changes.
Contraindications
- Do not use sildenafil with nitrates (e.g., nitroglycerin) due to the risk of significant blood pressure drop.
- Contraindicated in individuals with severe heart conditions, recent heart attacks, or strokes.
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