HGH – Human Growth Hormone
Human growth hormone (HGH) is a vital natural substance produced by the anterior pituitary gland, crucial for normal human growth and development. Typically released from birth, growth hormone (GH) levels peak in late adolescence, declining as individuals enter their 20s. For over 40 years, GH has been utilized in treating specific medical conditions. However, in recent decades, the surge in popularity of GH suggests many seek it out, believing it can reverse aging, enhance physical performance, or aid in body composition. Among athletes, GH abuse is prevalent, ranking as one of the top three substances misused.
What is Human Growth Hormone?
Human growth hormone, often abbreviated as HGH or GH, facilitates cell production and regulates various metabolic processes throughout the body. Secreted by the anterior pituitary located at the base of the skull, GH works synergistically with other hormones to promote optimal growth and development. GH levels hit their peak during puberty, with significant decreases observed around age 40.
HGH can be easily accessed in health food stores and wellness spas, often sold under various brand names, including Genotropin®, Humatrope®, Norditropin®, Nutropin®, Saizen®, and Serostim®.
Pharmacology of GH
Most available GH is produced via recombinant DNA technology, with two synthetic types: somatropin and somatrem. Both forms exhibit similar pharmacological actions, effectively mimicking natural GH once administered. GH binds to receptors in tissues, stimulating a range of cellular activities and exerting multiple physiological effects, including metabolism regulation and increased skeletal and muscle mass. GH levels typically rise during stress, sleep, and exercise.
Conditions Affecting GH Levels
Imbalances in GH can lead to medical conditions. An excess of HGH may cause acromegaly, resulting in enlarged extremities and serious health complications, or pituitary gigantism, marked by extreme height due to excessive GH secretion. Conversely, GH deficiency can result in various health issues, including significant short stature problems.
Approved Clinical Uses of GH
The FDA has authorized several injectable forms of HGH, available only through a licensed physician’s prescription. Initially approved in 1985 for conditions like growth hormone deficiency (GHD) and its related syndromes, HGH is now recognized for treating various medical conditions, including Turner syndrome, chronic renal insufficiency, and adult growth hormone deficiency due to pituitary tumors. Evidence suggests that HGH injections can lead to:
- increased muscle mass and bone density
- decreased body fat
- improved cognitive function
- enhanced exercise performance
- better cardiovascular tolerance
Dosage of GH
HGH is never taken orally; it is always administered via injection—subcutaneous or intramuscular. Once in the bloodstream, GH acts rapidly, although dosing requirements vary based on IGF levels and are commonly based on body weight. Typical doses for adults range from 0.01 to 0.1 mg/kg, determined by the product type and its intended use. Available as powder or liquid, the powder is dissolved in saline before injection.
Side Effects of Growth Hormone
While effective, GH can lead to various side effects, including:
- generalized edema
- carpal tunnel syndrome
- joint and muscle pain
- neuropathies (numbness and tingling)
- elevated blood glucose levels
Prescription Requirements for GH
HGH prescription is strictly regulated for specific FDA-approved purposes; however, off-label uses exist, notably for athletic performance and anti-aging treatments. Many off-label uses lack FDA endorsement due to the risk-to-benefit ratio. Patients must consider the significant potential side effects before initiating HGH therapy.
Potential Risks of Taking GH
The use of GH carries the risk of overdose, potentially resulting in severe conditions like acromegaly. Furthermore, GH’s role in cell growth raises concerns that it may inadvertently foster the proliferation of cancer cells, leading to types such as leukemia and prostate cancer. Less severe side effects include fluid retention, joint pain, and type 2 diabetes. Those exploring GH for anti-aging should weigh the therapy’s risks against its purported benefits.
Off-Label Uses
Bodybuilding and anti-aging are the primary off-label uses for HGH. Abused by many athletes, GH’s widespread availability poses legal challenges, with serious penalties for possession or distribution. Bodybuilders often combine GH with other drugs, making it difficult to assess its singular effects. Monthly costs for GH may range from $500 to $2000, with the risk of obtaining counterfeit products.
Anti-Aging
Many individuals seek GH for anti-aging benefits, desiring to eliminate wrinkles and restore youthful appearance. However, the FDA does not approve GH for anti-aging therapies, and evidence supporting its effectiveness in this realm is lacking. Despite the substantial financial investments—often upwards of $20,000 annually for injections—many fall victim to ineffective substitutes marketed as HGH.
Availability
Most individuals acquire HGH through illegal channels, including theft from pharmacies and unauthorized prescriptions from unethical physicians. Additionally, GH often crosses borders illicitly, including smuggling from Mexico or Europe, and is predominantly sold by online pharmacies operating without proper medical oversight. Many products are also misrepresented as sprays, pills, or topical gels, though their efficacy is questionable due to limited absorption rates.
Limitations of Testing
Detecting synthetic GH in the body is challenging; current methods cannot identify usage beyond 48 hours post-injection. Athletes are often aware of these limitations, frequently inquiring about detection capabilities before drug use.
Sermorelin
Sermorelin, a newer drug derived from Geref, functions as a biological analog of growth hormone-releasing hormone (GHRH), stimulating natural GH production. Difficult to detect in blood or urine, it is a popular alternative among athletes seeking to evade testing. While effective over several weeks, Sermorelin is not a suitable replacement for those deficient in GH, costing between $300 and $1000 monthly.
Control Status
Growing concerns over HGH abuse prompted tighter federal regulations, including the 1990 Anabolic Steroids Control Act, categorizing illegal possession and distribution of GH as a crime. A 2007 bill aimed to classify HGH as a schedule III substance, reinforcing its status as a prohibited performance-enhancing drug by the World Anti-Doping Agency and the International Olympic Committee.
Aitmatov D. (verified owner) –
Sofortige Wirksamkeit! Pfizer Genotropin 1 vial (1x 36 IU) ist einfach das Beste.
Hélène E (verified owner) –
فعال منذ الاستخدام الأول. Pfizer Genotropin 1 vial (1x 36 IU) مدهش.
Wolfgang E (verified owner) –
Impressionné par les effets mais j’attendais un peu plus.
Bernard V. (verified owner) –
جيد جداً لكن ليس مذهلاً.
Yasir M. (verified owner) –
جيد، لكن كان لدي أفضل في الماضي.
Anonymous (verified owner) –
Really impressed with the quality and effectiveness.
Anonymous (verified owner) –
مهه.
Anonymous (verified owner) –
عمل جيداً معي، لكن صديقي حصل على نتائج أفضل مع علامة تجارية أخرى.
Marcel D. (verified owner) –
منتج جيد. يمكن أن يكون أقوى قليلاً.
Anh B. (verified owner) –
La qualità di Pfizer Genotropin 1 vial (1x 36 IU) è immediatamente evidente. Eccellente!
Guido L. (verified owner) –
Sono rimasto stupito dai risultati di Pfizer Genotropin 1 vial (1x 36 IU). Eccellente!
Seraj O. (verified owner) –
Middle of the road. Some effects but not impressive.
Anonymous (verified owner) –
Works as advertised. No surprises.
Alon X. (verified owner) –
Buona roba.
Anonymous (verified owner) –
This Pfizer Genotropin 1 vial (1x 36 IU) is simply exceptional.
Anonymous (verified owner) –
Casi perfecto. Solo pequeños problemas con la entrega.
George Q. (verified owner) –
Хороший продукт. Работает достаточно хорошо.
Uzma C (verified owner) –
جودة ممتازة، نتائج ممتازة. Pfizer Genotropin 1 vial (1x 36 IU) جيد جداً.
Anonymous (verified owner) –
Remarkable improvement in just weeks.
Anonymous (verified owner) –
Will never use another brand again after trying Pfizer Genotropin 1 vial (1x 36 IU).
Addison V. (verified owner) –
使用Pfizer Genotropin 1 vial (1x 36 IU)后短时间内获得惊人的效果。
Paulo N. (verified owner) –
Impressed with the effects but expected a bit more.
Oscar D (verified owner) –
优质产品，但发货有点慢。
Anonymous (verified owner) –
Efficacia straordinaria. Pfizer Genotropin 1 vial (1x 36 IU) funziona alla perfezione.
Fedor Z. (verified owner) –
Works well but a bit expensive compared to others.
Amina W (verified owner) –
Exceeded all my expectations! Pfizer Genotropin 1 vial (1x 36 IU) is truly amazing.
Revaz E. (verified owner) –
منتج جيد لكن العبوة يمكن أن تكون أكثر تميزاً.
Anonymous (verified owner) –
Pfizer Genotropin 1 vial (1x 36 IU) hat meine Erwartungen bei weitem übertroffen. Ausgezeichnet!
Nodir M. (verified owner) –
坚固的产品。完成它应该做的事情。
Anonymous (verified owner) –
不值这个价钱。
Anonymous (verified owner) –
Presque parfait. Juste de petits problèmes avec la livraison.
Anonymous (verified owner) –
Efeitos extraordinários. Pfizer Genotropin 1 vial (1x 36 IU) funciona perfeitamente.
Nathan L. (verified owner) –
Producto de la más alta calidad. Pfizer Genotropin 1 vial (1x 36 IU) es impecable.
Murat D (verified owner) –
Estou entusiasmado com este Pfizer Genotropin 1 vial (1x 36 IU). Desempenho excepcional.
Anonymous (verified owner) –
Strength through the roof.
Pranee M (verified owner) –
Could not imagine better results.
Kenta A. (verified owner) –
Muito bom.
Marion K. (verified owner) –
Far superior to local alternatives.
Khadija B (verified owner) –
Excellent produit à tous égards. Pfizer Genotropin 1 vial (1x 36 IU) est de première classe.
Artur Q. (verified owner) –
Meglio di molti altri che ho provato.
Tengiz C (verified owner) –
Pfizer Genotropin 1 vial (1x 36 IU) hat jede meiner Erwartungen übertroffen. Fantastisch!
Anonymous (verified owner) –
Muito bom. Provavelmente pedirei novamente.
Anonymous (verified owner) –
This Pfizer Genotropin 1 vial (1x 36 IU) is truly outstanding.
Anonymous (verified owner) –
Produto de primeira qualidade. Pfizer Genotropin 1 vial (1x 36 IU) é excelente.
Anonymous (verified owner) –
The difference was immediate.
Anonymous (verified owner) –
Habe bessere Ergebnisse mit viel günstigeren Alternativen erzielt.
Ole L. (verified owner) –
منتج من الدرجة الأولى. Pfizer Genotropin 1 vial (1x 36 IU) ممتاز.
Akira R. (verified owner) –
Effetti notevoli fin dal primo utilizzo. Pfizer Genotropin 1 vial (1x 36 IU) è incredibile!
Louis A (verified owner) –
很划算。相当令人印象深刻。
Anonymous (verified owner) –
منبهر بالتأثيرات لكنني كنت أتوقع المزيد قليلاً.
Anonymous (verified owner) –
Finalmente un prodotto che mantiene le promesse. Pfizer Genotropin 1 vial (1x 36 IU) è incredibile.
Marina V (verified owner) –
Excepcional en todos los aspectos. Pfizer Genotropin 1 vial (1x 36 IU) es un producto fantástico.
Anonymous (verified owner) –
Finalmente um produto que cumpre suas promessas. Pfizer Genotropin 1 vial (1x 36 IU) é incrível.
Anonymous (verified owner) –
Prodotto solido. Fa quello che deve fare.
Sofia A (verified owner) –
Absolutely love it.
Anonymous (verified owner) –
Premium grade
Ryosuke B (verified owner) –
使用Pfizer Genotropin 1 vial (1x 36 IU)获得了令人难以置信的效果。强烈推荐。
Lina K (verified owner) –
This is what excellence looks like.
Yuki Y. (verified owner) –
Qualità eccellente. Pfizer Genotropin 1 vial (1x 36 IU) è un prodotto superiore.
Onyeka S (verified owner) –
جيد، لكن كان لدي أفضل في الماضي.
Anonymous (verified owner) –
قيمة ممتازة مقابل المال. منبهر إلى حد ما.
Moshe M (verified owner) –
The difference between this and other brands is night and day. This is pharmaceutical grade quality without question.
Mio N (verified owner) –
جودة ممتازة، نتائج ممتازة. Pfizer Genotropin 1 vial (1x 36 IU) جيد جداً.
Anonymous (verified owner) –
Pure power in every dose.
Antoine R. (verified owner) –
Заметная разница после использования Pfizer Genotropin 1 vial (1x 36 IU). Фантастика!
Brayden O (verified owner) –
效果很好，但比预期花费了更长的时间。
Anonymous (verified owner) –
Efficace dès la première utilisation. Pfizer Genotropin 1 vial (1x 36 IU) est étonnant.
Anonymous (verified owner) –
Sto vedendo buoni miglioramenti con Pfizer Genotropin 1 vial (1x 36 IU). Non perfetto ma buono.
Anonymous (verified owner) –
Solider Kauf. Größtenteils zufrieden.
Yusuke K (verified owner) –
Außerordentliches Produkt. Pfizer Genotropin 1 vial (1x 36 IU) funktioniert einwandfrei.
Marcin O. (verified owner) –
¡Justo lo que necesitaba! Pfizer Genotropin 1 vial (1x 36 IU) ha superado mis expectativas.
Csaba G. (verified owner) –
La qualité de Pfizer Genotropin 1 vial (1x 36 IU) est immédiatement évidente. Excellent !
Teuila S (verified owner) –
Elite quality.
Lam V (verified owner) –
منتج من الدرجة الأولى. Pfizer Genotropin 1 vial (1x 36 IU) ممتاز.
Hailey L. (verified owner) –
Makes everything else seem weak.
Amani N (verified owner) –
Great results but took a bit longer than expected.
Anonymous (verified owner) –
Pure power in every dose.
Ali U. (verified owner) –
Outstanding in every respect.
Anonymous (verified owner) –
Incredible.
Ilona J (verified owner) –
Fantastico! Pfizer Genotropin 1 vial (1x 36 IU) è un prodotto eccellente.
Elena A (verified owner) –
Can’t imagine using anything else now.
Onyekachi F. (verified owner) –
很好的投资。Pfizer Genotropin 1 vial (1x 36 IU)是一款出色的产品。
Jean R (verified owner) –
Die Qualität von Pfizer Genotropin 1 vial (1x 36 IU) ist der Konkurrenz deutlich überlegen. Sehr gut!
Anonymous (verified owner) –
Ce Pfizer Genotropin 1 vial (1x 36 IU) fonctionne parfaitement. Excellent achat !
Anonymous (verified owner) –
No complaints. Does the job well.
Advait G (verified owner) –
Quase tão bom quanto minha marca habitual.
Hatem N (verified owner) –
最高质量的产品。Pfizer Genotropin 1 vial (1x 36 IU)完美无瑕。
Anonymous (verified owner) –
Superior performance enhancer.
György V. (verified owner) –
Meglio di molti altri che ho provato.
Anonymous (verified owner) –
Truly outstanding product.
Sebastian L. (verified owner) –
Überlegene Qualität zu jedem anderen ähnlichen Produkt. Pfizer Genotropin 1 vial (1x 36 IU) ist fantastisch.
Anonymous (verified owner) –
Disappointing results. Wouldn’t recommend.
Hanan S (verified owner) –
¡Me encanta este Pfizer Genotropin 1 vial (1x 36 IU)! Es exactamente lo que estaba buscando.
Fernando F (verified owner) –
No competition whatsoever.
Rana B. (verified owner) –
В целом доволен своей покупкой.
Anonymous (verified owner) –
استثمار يستحق كل قرش. Pfizer Genotropin 1 vial (1x 36 IU) استثنائي.
Anonymous (verified owner) –
Prestazioni solide da questo Pfizer Genotropin 1 vial (1x 36 IU).
Magnus W. (verified owner) –
Good stuff.
Anonymous (verified owner) –
Sofortige Wirksamkeit. Pfizer Genotropin 1 vial (1x 36 IU) ist außerordentlich.
Marama W. (verified owner) –
Unmatched in quality and results.
Anonymous (verified owner) –
Der Unterschied mit Pfizer Genotropin 1 vial (1x 36 IU) ist äußerst bemerkenswert. Außergewöhnliche Ergebnisse!
Guadalupe M (verified owner) –
The pinnacle of supplementation.
Pongsak K (verified owner) –
Die Qualität von Pfizer Genotropin 1 vial (1x 36 IU) ist der Konkurrenz deutlich überlegen. Sehr gut!
Armen L (verified owner) –
فعالية فورية. Pfizer Genotropin 1 vial (1x 36 IU) استثنائي.
Anonymous (verified owner) –
Really good quality. Would recommend.
Xiulan Q (verified owner) –
Solid performance from this Pfizer Genotropin 1 vial (1x 36 IU).