Mesterolone – Proviron
Proviron, known for its anti-estrogenic activity, works by obstructing estrogen receptors in the brain, thereby promoting a rise in gonadotropins (LH and FSH), which stimulate the testes to produce more testosterone. However, it lacks direct anabolic or androgenic effects.
Synthesized in the 1970s, Proviron vanished from the market by the late 1990s, with Schering ceasing its production. Online sellers claiming to offer Proviron are often questionable, and the authenticity of the product remains uncertain, as it is reportedly smuggled from regions like Asia, Russia, and Mexico.
Initially, the drug was explored for treating depression and anxiety in both men and women. Studies revealed Proviron’s capacity to elevate gonadotropin levels and testosterone, leading to its use in addressing fertility issues. Currently, Proviron is unavailable for medical use, and much of what is accessible online is likely counterfeit.
Indications
Historically, Proviron was prescribed for testosterone deficiency and male infertility associated with hypothalamic, pituitary, or testicular dysfunction.
Pharmacology
Proviron exhibits more androgenic than anabolic activity, often utilized by athletes and bodybuilders to mitigate testosterone suppression resulting from prolonged anabolic steroid use. Many bodybuilders report dissatisfaction with the results, citing no significant gains in muscle mass or strength. Concerns about the availability of genuine Proviron and the prevalence of counterfeit products complicate its use.
Proviron shares anti-estrogen properties similar to Nolvadex or Arimidex, helping alleviate common side effects of anabolic steroids such as breast enlargement and water retention. Some users claim it enhances muscle definition, but results remain ambiguous due to concurrent anabolic steroid use. Most athletes have gravitated towards using Arimidex or Nolvadex instead.
Females
Proviron has been used by female athletes, but responses vary widely. Given its anti-estrogenic nature, female users are advised to consult healthcare professionals.
Dosage
The recommended Mesterolone dosage is 25 mg taken orally 2-3 times daily over several months, followed by maintenance therapy. Proviron is rapidly absorbed and boasts a long half-life of 12-24 hours, remaining detectable in urine for at least 2 weeks post-administration. Due to its limited efficacy as an anti-estrogen, it’s typically used alongside Tamoxifen or Arimidex during washout phases.
Side Effects
Though rare, Proviron can cause distressing side effects, including:
- painful erections
- loss of libido
- general fatigue
- deepening voice
- excess hair growth
- acne and oily skin
Contraindications
Proviron is not recommended for:
- children
- pregnant women
- individuals with liver dysfunction
- those with prostate cancer
- people with known allergies
Cost
When available, Proviron is costly, with its quality and purity often questioned. Typically found only on the black market, a 20 mg tablet can range from $3 to $4, with no guarantees against counterfeits.
Detection
Considered a banned substance by most sports organizations, Proviron can be detected in urine for up to 2 weeks following the last dose due to its long half-life.
Legal
Possessing Proviron is not illegal, but it is prohibited in most competitive sports. In the United States, it falls under the Controlled Substance Act as a Schedule 3 drug.
Final Word
Proviron has largely become a relic of the past. Genuine products are unavailable, and current offerings are likely counterfeit or adulterated. For those keen on enhancing their physique, alternatives like Arimidex are strongly recommended.
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