Testosterone Enanthate
Testosterone plays a crucial role in the development of male sex organs and the maintenance of secondary sexual characteristics, impacting the growth of the prostate, testes, seminal vesicles, penis, and scrotum while promoting overall body growth. As an androgenic hormone with significant anabolic properties, it enhances protein synthesis and supports a positive nitrogen balance when combined with a low-calorie diet.
Additionally, testosterone slightly boosts red blood cell production by stimulating EPO synthesis in the kidneys, increasing oxygen transport throughout the body.
Long-term use of testosterone can lead to the inhibition of gonadotropin release from the pituitary gland through negative feedback. In high doses, it may even suppress spermatogenesis.
Dosage
Testosterone enanthate (Delatestryl) has a slow dissolution rate post-intramuscular injection, with a recommended frequency of 1-2 times per month. This esterified form is to be administered via an intramuscular injection, enhancing the duration of action of testosterone. The product appears as a colourless to slightly yellow sesame oil suspension, with a typical dose of 250-500 mg once monthly for medical applications.
Indications
Delatestryl is prescribed for conditions of testosterone deficiency, including:
- primary hypogonadism, resulting from testicular damage
- hypogonadism due to pituitary dysfunction
- delayed puberty
In females with breast cancer, testosterone can inhibit estrogen effects, serving as an alternative to ovarian removal. Often, long-term therapy is necessary for developing secondary sexual characteristics and ensuring adequate growth.
Duration
The duration of testosterone enanthate treatment varies based on age, sex, diagnosis, response to therapy, and side effects. Generally, the drug is well-tolerated when prescribed correctly. Injections should be administered to the gluteal muscles or the outer thigh, avoiding intravenous use, and the injection site should be rotated to prevent abscesses. The maximum dosage should not exceed 1000 mg monthly due to its prolonged activity, and injections should be evaluated for clarity prior to use. Treatment typically lasts from 4-6 months.
Bodybuilders
Delatestryl is popular among bodybuilders during the off-season due to its prolonged presence in the system. However, it’s advised to avoid use during active competition periods. The anabolic and androgenic effects may take 3-4 weeks to manifest, and many bodybuilders combine it with other anabolic substances such as GH/thyroxine.
Due to testosterone’s conversion to estrogen in adipose tissue, bodybuilders may experience breast enlargement and water retention. For muscle mass and strength enhancement, doses typically range from 250-1000 mg/week, but higher doses can yield significant side effects. Beginners are encouraged to start with lower doses. The gradual increase in protein mass contributes to improved performance under intense training. Delatestryl’s benefits include enhanced health, increased athletic performance, and a favorable nitrogen balance. Research indicates this drug can boost performance and muscle mass while remaining undetectable in urine for weeks—a compelling advantage despite some retaining water. To mitigate breast enlargement, cycling with Arimidex or Tamoxifen is common.
Women
Testosterone analogues can lead to virilization in women if used for prolonged periods, with signs including deepening voice, excessive hair growth, menstrual irregularities, mood swings, and clitoral enlargement. Upon noticing such symptoms, it is crucial to cease use, as some effects may be irreversible.
Side Effects
Like all anabolic steroids, testosterone enanthate carries potential side effects, though most are mild and manageable. Common side effects that may emerge after 3-4 months of therapy include:
- bleeding irregularities
- virilizing effects
- deepening voice
- clitoral enlargement
- gynaecomastia
- painful erections
- hair loss, acne, oily skin
- water retention
- nausea, vomiting, jaundice
- rare liver cancer
- mental changes, depression, headaches, anxiety
- increased serum cholesterol
While several side effects are reversible, breast enlargement and certain virilizing effects may not be. Concurrent estrogen use may not effectively mitigate these effects.
In children, testosterone must be monitored closely to prevent accelerated bone maturation without compensatory linear growth, which can result in anatomical distortions, particularly in the jaw and face.
Warnings
Exercise caution when using testosterone in patients with:
- breast cancer and hypercalcemia
- liver dysfunction
- prostate cancer
- cardiac issues
Reports of dry cough and breathing difficulties post-injection have been associated with the oil formulation or impurities.
Regular monitoring of liver enzymes and blood hematocrit levels is advised for all individuals using testosterone to ensure safety.
Recognition
Due to its long half-life, testosterone enanthate can be detected in urine long after cessation. Testing methods currently available can identify testosterone or its metabolites up to 3-4 weeks post-use, and hair testing can reveal traces for 2-4 months. However, these tests are not foolproof, as approximately 50% may not detect steroid users based on testosterone/epitestosterone ratios.
Cost
The legal acquisition of testosterone enanthate can be challenging, leading many bodybuilders to source it from the black market. Generic formulations are prevalent in Europe and Mexico. Prices range from $10 to $20 for a 250 mg vial. In recent years, heightened scrutiny from the DEA has resulted in counterfeit products entering the market, making caution essential for consumers.
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