Tadalafil – Cialis
Tadalafil is a potent phosphodiesterase type 5 (PDE5) inhibitor used primarily under the brand name Cialis to address erectile dysfunction. It is also marketed as Adcirca for managing pulmonary arterial hypertension.
Mechanism of Action
- Tadalafil inhibits the enzyme PDE5, enhancing the level of cyclic guanosine monophosphate (cGMP).
- During sexual arousal, nitric oxide (NO) boosts cGMP levels in the penis tissues.
- This promotes smooth muscle relaxation and increases blood flow, facilitating the ability to achieve and maintain an erection.
Indications
- Primarily prescribed for treating erectile dysfunction in men.
- Effectively manages benign prostatic hyperplasia (BPH) and is indicated for pulmonary arterial hypertension in its Adcirca form.
Onset of Action
- Typically, Tadalafil begins to work within 30 minutes to 1 hour post-administration.
Duration of Action
- The therapeutic effects may persist for up to 36 hours, earning it the nickname “weekend pill.”
- This duration allows for the possibility of achieving an erection during this time if sexually stimulated.
Dosage
- Typical dosages for erectile dysfunction are 10 mg or 20 mg, taken approximately 30 minutes before anticipated sexual activity.
- For BPH, a daily dose of 5 mg is recommended.
Side Effects
- Common adverse reactions to Tadalafil include headaches, facial flushing, dyspepsia, dizziness, muscle pain, and backaches.
- Serious but rare side effects may include sudden vision or hearing loss.
Dapoxetine
Dapoxetine is indicated for managing premature ejaculation in men, marketed under the brand name Priligy.
Mechanism of Action
- This medication is a selective serotonin reuptake inhibitor (SSRI).
- Dapoxetine enhances serotonin availability by slowing its reuptake, impacting ejaculation control.
- Elevated serotonin levels effectively prolong the time to ejaculation.
Indications
- Indicated for men experiencing premature ejaculation.
- Specifically for males aged 18 to 64 who struggle with rapid ejaculation.
Onset of Action
- The onset typically occurs within 1 to 2 hours after consumption.
Duration of Action
- The effects generally last between 4 and 24 hours, influenced by dosage and individual response.
Dosage
- Common dosing for Dapoxetine varies from 30 mg to 60 mg, taken as needed.
- The initial recommended dosage is usually 30 mg, with potential adjustments made by healthcare providers based on response.
Side Effects
- Dapoxetine may cause side effects such as dizziness, headaches, nausea, drowsiness, fatigue, and dry mouth.
- Less frequently, users may experience hot flashes or changes in mood and sexual function.
Contraindications
- Not advised for those with severe liver or kidney issues, significant heart conditions, epilepsy, bipolar disorder, or those taking MAO inhibitors.
- Caution is advised against consuming alcohol alongside Dapoxetine, as it may heighten the risk of side effects.
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