Oxandrolone – Anavar
Anavar, a well-known mild anabolic steroid, is favored by athletes and bodybuilders alike due to its efficacy in promoting weight gain. One of the key benefits of Anavar is its ability to avoid estrogen conversion, significantly reducing the risk of gynecomastia and minimizing water retention, making it a popular choice among performance-enhancers.
Since its introduction to the North American market almost 50 years ago, Anavar was initially used to treat infertility disorders, various anemias, and patients suffering from severe weight loss in medical settings. However, its clinical applications have diminished over time. Anavar boasts two significant advantages over other anabolic steroids: it does not convert to estrogen and minimally impacts the hypothalamic pituitary axis at lower doses. This lack of conversion helps prevent breast enlargement in males and mitigates testosterone suppression, thereby reducing the likelihood of libido loss, impotence, and testicular atrophy, common side effects associated with many steroids.
Pharmacology
Oxandrolone, also known as Oxandrin, exhibits both anabolic and androgenic properties. At lower doses, it demonstrates selective anabolic effects, while higher doses can lead to increased androgenic activity. Overuse can suppress gonadotropin release from the hypothalamus, resulting in decreased testosterone synthesis. As with other anabolic steroids, Oxandrolone increases levels of ‘bad’ LDL cholesterol while decreasing ‘good’ HDL cholesterol, but remains unique for its non-conversion to estrogen at lower doses.
Indications
Oxandrolone’s clinical use is limited today; in the past, it treated various anemias and weight loss in HIV patients, along with trials for osteoporosis. After its widespread abuse led to Searle ceasing production in 1989, it resumed under Savient Pharmaceutical, known as Oxandrin. Some physicians still prescribe this drug to help moribund patients gain weight following trauma, burns, or serious infections, occasionally combining it with corticosteroids for cancer-related bone pain.
Dosage
The typical adult dosage for treating anemia or promoting weight gain ranges from 2.5 to 20 mg per day, divided into 2-4 doses. Individual responses can vary significantly, with some requiring doses as high as 30-150 mg per day over a treatment period of 3-6 weeks. Oxandrin is available in 2.5 mg and 10 mg tablet forms.
Although most side effects at lower doses are minor—like mild abdominal discomfort or nausea—higher doses can lead to more serious issues, including:
- jaundice
- rare hepatic necrosis
- liver cancer
- general malaise
- testicular atrophy
- hair loss
- breast enlargement
- abdominal cramps, nausea, bloating
- acne, oily skin
- diarrhea
- menstrual irregularities
Most side effects are reversible upon discontinuation of the drug.
Contraindications
Oxandrolone is contraindicated in patients with:
- suspected prostate cancer
- breast cancer (in both genders)
- pregnancy
- evidence of hypercalcemia
- allergy to anabolic steroids
Bodybuilders
Anavar is especially popular among bodybuilders for its quick absorption; it is best taken with meals. Typical dosing for men is one tablet twice daily, while women may require only one tablet daily. Many bodybuilders start with lower doses and often stack Anavar with other compounds like Dianabol, Winstrol, or Anadrol, as it presents fewer side effects at lower doses. Treatment durations typically range from 4-8 weeks, with recommended initial doses of around 5 mg per day, gradually increasing over 2-3 weeks.
Though Anavar is favored by women for its minimal virilizing effects at low doses, higher doses (exceeding 5 mg per day) or extended use (beyond 6 weeks) may result in signs of masculinization. Weight gain from Anavar generally occurs gradually, noticed after 3-4 weeks.
Possible signs of virilization include:
- deepened voice
- decreased libido
- clitoral enlargement
- acne
- excessive hair growth
Women experiencing virilization should discontinue use immediately. While some symptoms might revert upon cessation, others may be irreversible.
Warnings
Like any anabolic steroid, Anavar poses a risk to liver health, potentially causing jaundice and serious liver complications. Cases of liver dysfunction and tumors have been documented. Thus, regular monitoring of liver enzymes and possible annual ultrasounds are advisable for individuals taking this drug.
Overdose
Anavar is generally regarded as safe, with overdoses being unlikely to be life-threatening. However, adverse effects may be significant, necessitating an emergency room visit if overdose occurs. Standard treatment involves supportive care.
Costs
The cost for a supply of 100 tablets (2.5mg) Anavar varies between $100 and $150, though counterfeit products are prevalent in the market. Buyers should only procure from reputable sources. Genuine Anavar from pharmacies can range from $700-$1200 for 100 tablets, ensuring quality and safety.
Levels
Anavar metabolites are frequently detectable in urine, with most major sports organizations conducting regular anabolic steroid screenings. Metabolites can remain in the body for 7-14 days post-use.
Legal
Anavar is considered a controlled substance in the USA, making its sale and distribution illegal. The DEA monitors its trafficking both in pharmacies and online. In the U.S., possession of Anavar for non-clinical use is classified as a crime.
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