Oxandrolone – Anavar
Anavar is a mild anabolic steroid highly favored by athletes and bodybuilders for its ability to promote weight gain effectively.
A key appeal of Anavar among athletes is its non-aromatizing nature, which minimizes the risk of gynecomastia and reportedly reduces water retention.
Since its market introduction nearly 50 years ago, Anavar has transitioned from treating infertility, anemia, and cachexia to a more restricted clinical use. Its significant benefits compared to other anabolic agents include a lack of estrogen conversion and minimal impact on the hypothalamic-pituitary axis. This unique profile means users are less likely to experience common side effects such as loss of libido, impotence, or testicular atrophy.
Pharmacology
Oxandrin, the active compound, exhibits both anabolic and androgenic properties, mirroring some effects of testosterone. At low doses, it selectively promotes muscle growth, while at higher doses, it can trigger more pronounced androgenic effects. However, high doses may also impair gonadotropin release, consequently lowering testosterone production. Similar to other steroids, Oxandrin can raise levels of bad LDL cholesterol while lowering good HDL cholesterol. Notably, it remains non-aromatizing even at lower dosages.
Indications
While Oxandrolone is infrequently utilized in modern clinical settings, its application in treating various anemias and assisting weight restoration in severely ill patients still exists. Following misuse concerns in the late 1980s forcing its production halt by Searle, it has been resumed under the name Oxandrin by Savient Pharmaceutical. Some physicians now prescribe it for patients recovering from trauma, burns, or serious infections, often combined with corticosteroids for added benefits in treating cancer-related pain.
Dosage
The typical dosage for patients addressing anemia or requiring weight gain is 2.5 to 20 mg/day, divided into 2-4 doses. Patients may see results from lower doses, while others may require higher doses ranging from 30-150 mg/day over durations of 3 to 6 weeks. Product forms include 2.5 mg and 10 mg tablets.
Like all anabolic steroids, Oxandrin can carry side effects. At lower dosages, these might entail minor abdominal discomfort, nausea, or diarrhea, but at elevated doses serious effects can occur, including:
- jaundice
- rare hepatic necrosis
- liver cancers
- general malaise
- testicular atrophy
- hair loss
- breast enlargement
- stomach cramps, nausea, bloating
- acne, oily skin
- diarrhea
- menstrual irregularities
Fortunately, most side effects are reversible upon discontinuation of the drug.
Contraindications
Use of Oxandrolone is contraindicated in patients with:
- suspected prostate cancer
- breast cancer in both genders
- pregnancy
- evidence of hypercalcemia
- allergies to anabolic steroids
Bodybuilders
Anavar is a popular choice among bodybuilders due to its rapid absorption when ingested with food. Typically, men take one tablet twice daily, whereas women may limit their intake to one tablet daily. Many athletes begin at lower doses, often combining Anavar with other compounds like dianabol, winstrol, or anadriol, as it has fewer side effects. Treatment durations vary from 4 to 8 weeks. An initial recommended dosing is around 5 mg per day, gradually increasing over 2-3 weeks.
Women particularly appreciate Anavar for its minimal virilizing effects; however, doses exceeding 5 mg/day or durations over 6 weeks may lead to signs of masculinization. Weight gain associated with Anavar typically appears gradually within 3 to 4 weeks.
Signs of virilization include:
- deep voice
- decreased libido
- clitoral enlargement
- acne
- excessive hair growth
Women exhibiting virilizing symptoms should cease the drug immediately. While acne and excess hair growth may subside, other symptoms are not always reversible.
Warnings
All anabolic steroids, including Anavar, present liver damage risks and potential jaundice. Instances of liver dysfunction and tumors have been documented, with liver cancer representing the most severe complication. Regular monitoring of liver enzymes and periodic ultrasound assessments are advisable for users.
Overdose
Overdosing on Anavar is rare and typically not life-threatening; however, adverse effects may linger. If overdose occurs, immediate medical attention is crucial. Standard treatment for steroid overdose is supportive care.
Costs
The typical cost for 100 tablets (2.5 mg) of Anavar ranges from $100 to $150, albeit counterfeit versions are prevalent due to high demand. Reputable suppliers are essential for quality assurance, with authentic pharmacy-sourced options priced between $700 and $1200 for 100 tablets.
Levels
Anavar and its metabolites are detectable in urine, with major sports organizations regularly screening for anabolic steroids. Metabolite presence may last 7 to 14 days post last dose.
Legal
Anavar is classified as a controlled substance in the USA, making its sale and distribution illegal. The DEA actively monitors these transactions in pharmacies and online. Possession for personal use is also deemed a criminal act given its non-therapeutic status.
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