Tadalafil – Cialis
Tadalafil, a member of the phosphodiesterase type 5 (PDE5) inhibitors family, is recognized for its effectiveness as Cialis, primarily aimed at treating erectile dysfunction, and as Adcirca, utilized for pulmonary arterial hypertension.
Mechanism of Action
- Tadalafil inhibits the enzyme PDE5, preventing the breakdown of cyclic guanosine monophosphate (cGMP).
- Elevated levels of cGMP are stimulated during sexual excitement through increased release of nitric oxide (NO).
- This action promotes relaxation of smooth muscles in blood vessels, enhancing blood flow to the penis and facilitating the achievement and maintenance of an erection.
Indications
- Primarily, tadalafil is prescribed for erectile dysfunction in men.
- It additionally treats benign prostatic hyperplasia (BPH) and is available as Adcirca for pulmonary arterial hypertension.
Onset of Action
- Typically, tadalafil exhibits a rapid onset of action, taking effect within 30 minutes to 1 hour of ingestion.
Duration of Action
- The effects of tadalafil may persist for up to 36 hours, earning it the nickname “weekend pill“.
- This allows for prolonged opportunities for men to achieve an erection when sexually stimulated during this time.
Dosage
- For erectile dysfunction, the typical dosage ranges from 10 mg to 20 mg, taken as needed about 30 minutes before sexual activity.
- For BPH, a standard dosage is 5 mg daily.
Side Effects
- Commonly reported side effects include headache, facial flushing, indigestion (like nausea or diarrhea), dizziness, muscle pain, and backache.
- Serious side effects, such as sudden vision loss or hearing loss, may occur infrequently.
Contraindications
- Tadalafil is contraindicated with nitrates (e.g., nitroglycerin) due to the risk of a severe drop in blood pressure.
- It should not be used by patients with severe heart conditions, recent myocardial infarction, or stroke.
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