Clomiphene Citrate – Clomid
Clomiphene citrate (known as Clomid) is a synthetic, non-steroidal compound structurally akin to estrogen. Its primary role as an ovulatory stimulant makes it a popular choice in fertility treatments. By binding to estrogen receptors in the hypothalamus, Clomid effectively blocks the perception of actual estrogen levels, prompting the pituitary gland to release increased amounts of gonadotropins, including FSH and LH. This surge stimulates the ovaries and testes to boost the production of estrogen and testosterone, respectively.
This property has rendered clomiphene effective for treating women experiencing ovarian failure or seeking to induce ovulation. However, prolonged use may raise concerns, including an elevated risk of ovarian cancer.
Pharmacology
Clomid is particularly beneficial for women suffering from ovulatory dysfunction, identified through a detailed assessment of their menstrual cycles. Conditions such as polycystic ovarian syndrome and unexplained amenorrhea can hinder pregnancy, making Clomid a pertinent option. The treatment begins around the fifth day of the menstrual cycle and is typically administered for 3-6 cycles, with careful monitoring of body temperature and blood work to confirm ovulation.
Mode of Action
As a potent pharmaceutical agent, Clomid mimics estrogen’s activity but blocks estrogen receptors in the hypothalamus. This action signals the brain to perceive low estrone levels, stimulating a release surge of gonadotropins that in turn hyperstimulates the ovaries, enhancing estrogen production critical for fertilization.
Indications
Clomid is prescribed exclusively for women with ovulatory dysfunction, contingent on the following criteria:
- The individual is non-pregnant.
- Absence of ovarian cysts, verified via ultrasound.
- No presence of vaginal bleeding, warranting thorough examination to rule out cancer.
- Normal liver function tests.
- Although Clomid shows efficacy in female cases, its effects on male infertility remain under-researched. Occasionally, it has been used in males to boost LH and FSH levels, resulting in increased sperm count, though this is documented in limited case reports.
- Prescription dosage for infertility treatments.
Clomiphene, an odorless large molecule, is usually available in 50 mg tablets and soluble in various organic solvents, including alcohol.
Prior to Clomid therapy, patients must be thoroughly evaluated for gynecological and endocrine disorders. Ovulation generally occurs 5-10 days post-initiation of Clomid, with timing of intercourse crucial to coincide with ovulation.
The standard starting dose is 50 mg/day for 5 days, adjustable for those not achieving ovulation.
Body Building
Clomid is frequently misused among athletes, including both amateurs and professionals, often in conjunction with various anabolic steroids, HCG, and tamoxifen. Unlike many anabolic agents, Clomid can elevate testosterone levels by inducing a surge in LH without suppressing production.
Many anabolic steroids possess both androgenic and anabolic traits, and some can convert to estrogen via the enzyme aromatase, potentially causing gynecomastia among bodybuilders. Clomid’s ability to inhibit estrogen receptors mitigates this undesired effect, making it a favored choice for many in the bodybuilding community.
Clomid Dosage for Athletes
Used once daily, Clomid is recommended to be combined with low-potency anabolic steroids during a cycle. Bodybuilders typically transition to Clomid after a steroid cycle, which should commence within 7-10 days post-steroid cessation. Dosage for bodybuilders ranges from 50-100 mg/day for two weeks, with some advocating for increased dosages if results are unsatisfactory. This regimen, however, lacks formal medical endorsement.
Side Effects
When utilized as directed for short durations, Clomid is generally safe with most side effects being temporary. Common adverse reactions can include:
- Flushing
- Abdominal discomfort
- Nausea and vomiting
- Breast tenderness
- Headaches
- Abnormal vaginal bleeding
- General fatigue
- Hair loss
- Visual disturbances
One significant concern is the potential for visual changes due to the drug’s impact on the brain, which may compress ocular nerves when the pituitary gland is overstimulated. Subsequent vision changes, ranging from floaters to partial vision loss, have been reported, often reversing upon discontinuation.
Mood Changes
Mood alterations are also a noteworthy side effect, with users citing symptoms such as depression, anger, anxiety, and insomnia, albeit these phenomena occur in less than 1% of women treated.
Cost
Clomid requires a physician’s prescription for infertility treatment; however, it is widely available online. Pricing for clomiphene varies, averaging around $50-100 for a 100-pill supply.
Levels
Although Clomid remains accessible, its use is banned in professional sports, with detection in urine lasting 5-12 days post-administration. Advanced testing can also identify hormone ratios indicating potential abuse.
Katrin R (verified owner) –
Good quality though not quite as strong as I hoped.
Maki P (verified owner) –
Prodotto straordinario. Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) funziona alla perfezione.
Susan R (verified owner) –
Notevole differenza dopo aver usato Euro-Pharmacies Clomixin 20 tabs (50 mg/tab). Fantastico!
Anonymous (verified owner) –
This Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) delivers every time.
Maximilian K. (verified owner) –
Hervorragend. Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) ist ein erstklassiges Produkt.
Anonymous (verified owner) –
Best investment in my fitness.
Naomi I. (verified owner) –
Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) is just average compared to others I’ve tried.
Christian F. (verified owner) –
J’adore ce Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) ! C’est exactement ce que je cherchais.
Hayk P. (verified owner) –
فعال بالتأكيد، فقط ليس قوياً كما كنت آمل.
Anonymous (verified owner) –
Efficacité immédiate. Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) est extraordinaire.
Malak Y (verified owner) –
Very good.
Anonymous (verified owner) –
High-quality product. Will be a returning customer.
Anonymous (verified owner) –
After 2 months: completely transformed.
Hannes K (verified owner) –
Couldn’t be happier with the results.
Anonymous (verified owner) –
Non comprerei di nuovo.
Prakash V. (verified owner) –
Exceptionally effective.
Anonymous (verified owner) –
Optimal effects every time.
Anonymous (verified owner) –
Amazing quality. Worth every cent.
Anonymous (verified owner) –
It’s alright. Might try something else next time.
Anonymous (verified owner) –
Sono rimasto sbalordito dall’efficacia di Euro-Pharmacies Clomixin 20 tabs (50 mg/tab). Incredibile!
Anonymous (verified owner) –
Mehr oder weniger was ich erwartet habe. Gutes Produkt.
Anonymous (verified owner) –
Worked well but had some minor side effects.
Anonymous (verified owner) –
Non potevo chiedere di meglio. Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) è semplicemente perfetto.
Anonymous (verified owner) –
Incredible strength gains. Noticing visible changes already after just two weeks.
Marguerite Y (verified owner) –
Efeitos extraordinários. Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) funciona perfeitamente.
Anonymous (verified owner) –
Keine Beschwerden. Erledigt seinen Job gut.
Anonymous (verified owner) –
I’m amazed at how well this works.
Anonymous (verified owner) –
Ich war verblüfft über die Wirksamkeit von Euro-Pharmacies Clomixin 20 tabs (50 mg/tab). Unglaublich!
Federico J. (verified owner) –
Definitivamente faz o que promete. Só não é tão dramático quanto eu esperava.
Aisha W (verified owner) –
Molto buono ma non straordinario.
Anonymous (verified owner) –
В лучшем случае посредственно.
Anonymous (verified owner) –
قيمة ممتازة مقابل المال. Euro-Pharmacies Clomixin 20 tabs (50 mg/tab) يستحق كل قرش.
Anonymous (verified owner) –
World class quality.
Igor M (verified owner) –
Literally perfect.
Anonymous (verified owner) –
Phenomenal in every respect.
Isikeli C (verified owner) –
我对这个Euro-Pharmacies Clomixin 20 tabs (50 mg/tab)感到兴奋。表现出色。
Young-ho F. (verified owner) –
High quality. Great results.