Oxandrolone – Anavar
Anavar is a renowned anabolic steroid, primarily embraced by athletes and bodybuilders for its ability to assist in weight gain. Its appeal lies in the absence of conversion to estrogen, minimizing gynecomastia and reducing water retention.
Introduced nearly 50 years ago in North America, Anavar initially served to treat various infertility disorders, anemias, and individuals experiencing severe weight loss in clinical settings. However, its clinical usage has diminished over the years. Unlike many other anabolic steroids, Anavar boasts two key advantages: it does not convert to estrogen and has minimal impact on the hypothalamic-pituitary axis. This means users are less likely to experience side effects such as loss of libido, impotence, or testicular atrophy.
Pharmacology
Oxandrin functions as both an anabolic steroid and an androgenic drug, mirroring the effects of testosterone. It provides selective anabolic properties at lower doses while exhibiting androgenic activity at higher doses. At elevated levels, it may impact the hypothalamus and suppress gonadotropin release, decreasing testosterone synthesis. Similar to its counterparts, Oxandrin can elevate LDL cholesterol and lower HDL cholesterol, but remains unique as it doesn’t convert to estrogen at lower doses.
Indications
While infrequently prescribed in clinical medicine, Anavar was historically used for treating anemias, weight loss in HIV patients, and osteoporosis. Due to widespread abuse, production ceased in 1989, but Savient Pharmaceutical now manufactures it under the trade name Oxandrin. Today, some healthcare professionals may prescribe Oxandrin to assist moribund patients in gaining weight post-trauma, burns, or severe infections, sometimes in conjunction with corticosteroids for bone pain treatment in cancer cases.
Dosage
The typical adult dosage for anemia or weight gain ranges from 2.5 to 20 mg/day, divided into 2-4 doses. While some may respond to lower doses, others might need 30-150 mg/day, with a treatment duration of 3-6 weeks, gradually adjusting dosage as necessary. Oxandrin is available in tablet form, with 2.5 mg or 10 mg options.
Like other anabolic steroids, Oxandrin can present side effects. Mostly minor at lower doses—abdominal discomfort, nausea, or diarrhea—higher doses can lead to serious complications such as:
- Jaundice
- Rare hepatic necrosis
- Liver cancers
- General malaise
- Testicular atrophy
- Hair loss
- Breast enlargement
- Stomach cramps, nausea, bloating
- Acne, oily skin
- Diarrhea
- Menstrual irregularities
The majority of side effects are reversible upon discontinuation of the drug.
Contraindications
Oxandrolone should be avoided in conditions such as:
- Suspected prostate cancer
- Breast cancer, male or female
- Pregnancy
- Evidence of hypercalcemia
- Allergy to anabolic steroids
Bodybuilders
Anavar remains a favored choice among bodybuilders due to its high absorption rate when taken with meals. Males typically start with one tablet twice daily, while females usually take one tablet daily. Most bodybuilders begin at low doses and may combine Anavar with other anabolic agents like Dianabol, Winstrol, or Anadriol due to its minimal side effects. Treatment spans 4-8 weeks, with initial advice recommending 5 mg daily, progressively increasing over 2-3 weeks.
Women particularly favor Anavar for its limited virilizing effects at low doses. However, doses above 5 mg or extended treatment beyond 6 weeks can lead to virilization symptoms including:
- Deep voice
- Decreased libido
- Clitoral enlargement
- Acne
- Excessive hair growth
Women experiencing virilization should cease taking the drug immediately, as some effects may not be reversible.
Warnings
All anabolic steroids, including Oxandrolone, pose a risk of liver damage and jaundice. Numerous cases of liver dysfunction and tumors have been reported. Liver cancer is the most severe complication associated with all anabolic steroids, thus routine monitoring of liver enzymes is advisable.
Overdose
Overdose scenarios with Anavar are rare and typically not life-threatening, though discomfort may persist. In cases of overdose, visiting the emergency room is highly recommended, with supportive treatment being the standard approach.
Costs
The cost of Anavar for 100 tablets (2.5 mg) ranges from $100 to $150. However, counterfeit products are prevalent, so purchasing from reputable sources is crucial. Authentic Anavar from pharmacies may cost between $700 to $1200 for 100 tablets.
Levels
Anavar and its metabolites can easily be detected in urine. Major sports organizations routinely test for anabolic steroids, with Anavar metabolites persisting in the body for 7-14 days post-use.
Legal
As a controlled substance in the USA, the sale and distribution of Anavar are strictly prohibited. The DEA monitors its availability in pharmacies and online, and personal possession is considered a crime due to its lack of clinical approval in the USA.
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