Testosterone Enanthate
Testosterone plays a crucial role in the development of male sex organs and maintaining secondary sexual characteristics. This vital hormone influences the growth of the prostate, testes, seminal vesicles, penis, and scrotum while promoting overall body growth. As an androgenic hormone, testosterone also exhibits anabolic properties, enhancing protein synthesis and fostering a positive nitrogen balance when combined with a nutrient-rich, low-calorie diet.
Furthermore, testosterone slightly boosts red blood cell production by stimulating the synthesis of EPO in the kidneys, ultimately enhancing oxygen-carrying capacity.
Prolonged use of testosterone can inhibit the secretion of gonadotropins from the pituitary gland through a negative feedback mechanism, and at higher doses, it may even suppress spermatogenesis.
Dosage
Testosterone enanthate (Delatestryl) should be injected intramuscularly and is typically administered only 1-2 times per month due to its slow dissolution. This esterified form of testosterone ensures prolonged activity, presenting as a colourless to slightly yellow sesame oil suspension. Medical guidelines recommend a monthly dosage of 250-500mg.
Indications
Delatestryl is indicated for treating testosterone deficiency scenarios such as:
- Primary hypogonadism due to testicular injury
- Hypogonadism from pituitary failure
- Delayed puberty
In women with breast cancer, testosterone may impede estrogen effects, serving as a non-surgical alternative for ovariectomy.
Most individuals with testosterone deficiency require therapy for an extended duration until appropriate secondary sexual characteristics are developed.
Duration
The duration of testosterone enanthate treatment is tailored according to age, sex, diagnosis, treatment response, and side effects. When prescribed correctly, this drug is generally well tolerated. Always inject into the gluteal muscles and rotate injection sites to mitigate abscess risk. Fortnightly injections are rare, and the maximum dosage should not exceed 1000 mg per month due to its long-acting nature. Before administration, ensure the suspension is clear to avoid using expired or inactive products. The treatment duration generally spans 4-6 months. Store the drug at room temperature.
Bodybuilders
Bodybuilders often incorporate Delatestryl during off-season cycles due to its extended presence in the body, recommending avoidance during competitive seasons. While the drug exhibits notable anabolic and androgenic effects, results may take 3-4 weeks to manifest. Many also utilize additional anabolic hormones such as GH or thyroxine concurrently.
Caution is advised as testosterone can convert to estrogen in adipose tissue, leading to potential breast enlargement and water retention. Typical dosages for muscle mass enhancement range from 250-1000 mg per week, with higher doses correlated to increased risk of side effects. Gradual protein mass increases and heightened endurance during strenuous activity are often noted. Preferred for its availability and numerous benefits, testosterone enanthate fosters health, boosts athletic performance, and asserts a positive nitrogen balance. Reports indicate its ability to selectively lower fat while increasing muscle mass. Scientific studies affirm its capability to enhance performance without detection in urine tests for initial weeks. Water retention may be pronounced, prompting some to use diuretics. To avert breast enlargement, cycles of testosterone enanthate are often combined with Arimidex or Tamoxifen, typically alternating 4-6 weeks on and off, with Arimidex during the washout period.
Women
All testosterone analogues risk inducing virilizing effects with prolonged use. In women, these effects may manifest as voice deepening, excessive hair growth, irregular menstruation, mood fluctuations, and clitoral enlargement. At the first sign of virilization, discontinuation of the drug is recommended, as some effects may be irreversible.
Side Effects
While many experience mild side effects, they typically manifest after 3-4 months of therapy. Common side effects include:
- Irregular bleeding
- Virilizing traits
- Voice deepening
- Clitoral enlargement
- Gynaecomastia
- Painful erections
- Hair loss, acne, oily skin
- Water retention
- Nausea, vomiting, jaundice
- Rare liver cancer
- Mental changes, including depression, headaches, anxiety
- Elevated cholesterol
Most side effects are reversible, though breast enlargement and certain virilizing effects may not be. Concurrent estrogen use to mitigate virilization sometimes proves ineffective. In children, testosterone use must be closely monitored due to the risk of accelerated bone maturation without proportional linear growth, potentially leading to anatomical abnormalities.
Warnings
Exercise caution in patients with:
- Breast cancer and hypercalcemia
- Liver dysfunction
- Prostate cancer
- Heart conditions
Reports of dry cough and breathing issues post-injection have been linked to the oil suspension or impurities.
Regular liver enzyme and blood haematocrit checks are essential for all testosterone users to ensure safety.
Recognition
With a long half-life, testosterone enanthate remains detectable in urine long after use, with current testing methods identifying it or its metabolites for 3-4 weeks post-cessation. In some cases, traces can be found in hair up to 2-4 months after discontinuation.
However, it is crucial to note that testosterone testing is not foolproof, and approximately 50% of users may go undetected based on testosterone/epitestosterone ratios.
Cost
Legal acquisition of testosterone enanthate can be challenging, with many bodybuilders sourcing it from the black market. Generic formulations are readily available in Europe and Mexico, with costs ranging from $10-$20 for a 250mg vial. Due to heightened scrutiny by the DEA over two decades, the risk of counterfeit products exists. Ultimately, the buyer must exercise caution and discretion.
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