Oxandrolone – Anavar
Anavar, known as Oxandrolone, is a mild anabolic steroid favored by athletes and bodybuilders for its weight-gain properties. Its unique appeal lies in its ability to prevent conversion to estrogen, minimizing the risk of gynecomastia and reducing water retention.
First available in North America over 50 years ago, Anavar initially catered to conditions such as infertility, anemia, and muscle wasting in hospitalized patients. Although its clinical use has declined, Anavar offers distinct advantages: it avoids estrogen conversion and exerts minimal influence on the hypothalamic-pituitary axis. This ensures users experience fewer side effects compared to other anabolic steroids, including no occurrences of loss of libido, impotence, or testicular atrophy.
Pharmacology
Oxandrolone operates as a dual-action anabolic steroid with androgenic drug qualities. While low doses promote selective anabolic effects, higher doses increase androgenic activity. At elevated doses, Anavar can suppress gonadotropins, potentially leading to reduced testosterone synthesis. Notably, this steroid raises LDL cholesterol levels while reducing HDL cholesterol, with its unique formulation preventing estrogen conversion at low doses.
Indications
Anavar’s clinical applications have waned, having previously been used to address anemias and weight loss in HIV patients, and even osteoporosis. Following widespread abuse, Searle discontinued its production in 1989. Currently manufactured by Savient Pharmaceutical under the name Oxandrin, it may still be prescribed for patients requiring weight gain post-trauma or infection, occasionally paired with corticosteroids to alleviate bone pain in cancer patients.
Dosage
For anemia or weight gain, adult dosages typically range from 2.5 to 20 mg daily, divided into 2-4 doses. Individual responses vary, with some requiring 30-150 mg/day. Treatment duration averages 3-6 weeks, with gradual dose increases if no response is observed within the first four weeks. Oxandrin is available in tablet form at 2.5 mg and 10 mg doses.
While many side effects manifest at higher doses, low doses often yield only minor effects like abdominal discomfort and nausea. Potential high-dose side effects include:
- Jaundice
- Rare hepatic necrosis
- Liver cancers
- General malaise
- Testicular atrophy
- Hair loss
- Breast enlargement
- Stomach cramps, nausea, bloating
- Acne, oily skin
- Diarrhea
- Menstrual irregularities
Most side effects are reversible upon discontinuation.
Contraindications
Oxandrolone should be avoided in individuals with:
- Suspected prostate cancer
- Breast cancer (male or female)
- Pregnancy
- Evidence of hypercalcemia
- Allergies to anabolic steroids
Bodybuilders
Anavar is popular among bodybuilders due to its effective absorption when taken with meals. Men typically take one tablet twice daily, while women generally require just one daily dose. Many athletes start at lower doses, often combining Anavar with other steroids like Dianabol, Winstrol, or Anadriol. Treatment cycles generally last between 4-8 weeks, with a recommended starting dose of 5 mg per day, increasing gradually over 2-3 weeks.
Women particularly benefit from Anavar’s low virilizing effects, but doses exceeding 5 mg per day or treatment durations beyond six weeks may lead to signs of masculinization, which can include:
- Deep voice
- Decreased libido
- Clitoral enlargement
- Acne
- Excessive hair growth
Women experiencing virilizing symptoms should discontinue use immediately, as some effects may become permanent.
Warnings
All anabolic steroids carry a risk of liver damage and jaundice, with Anavar being no exception. Liver dysfunction and growths can occur, and liver cancer remains a serious concern. Regular monitoring of liver enzymes and annual ultrasounds are advisable for users.
Overdose
Overdosing on Anavar is rare, as it is generally safe. Even large doses may not pose immediate life-threatening risks, though adverse effects can be uncomfortable. Emergency care is recommended in any overdose situation, and supportive treatment is standard.
Costs
Prices for 100 tablets of Anavar (2.5 mg) typically range from $100 to $150, but demand has proliferated counterfeit variants. Buyers should procure from reputable sources to avoid risks, as expressions of legality remain murky, especially with supplies from Mexico. When procuring genuine pharmaceutical Anavar, costs can soar to $700-$1200 for 100 tablets.
Levels
Anavar and its metabolites are detectable in urine tests, with many sports organizations conducting regular screenings. Metabolites can remain in the body for 7-14 days post-use.
Legal
In the USA, Anavar is classified as a controlled substance, making its sale and distribution illegal. The DEA monitors its presence in pharmacies and online, with personal possession also considered a crime due to its non-clinical status.
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