Tadalafil – Cialis
Tadalafil is a potent medication classified among phosphodiesterase type 5 (PDE5) inhibitors, marketed under the brand name Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension.
Characteristics of Tadalafil
Mechanism of Action
- Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE5), which usually degrades cyclic guanosine monophosphate (cGMP).
- Upon sexual stimulation, nitric oxide (NO) release increases cGMP levels.
- This results in relaxation of smooth muscle in blood vessels, enhancing blood flow to the penis for achievable and sustained erections.
Indications
- Primarily, Tadalafil treats erectile dysfunction in men.
- Also indicated for the management of benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension, in its Adcirca form.
Onset of Action
- Typically, Tadalafil takes effect within 30 minutes to 1 hour after administration.
Duration of Action
- The effects can last up to 36 hours, earning it the nickname “weekend pill.”
- This duration allows men to experience erections throughout this window upon sexual stimulation.
Dosage
- For treating erectile dysfunction, the recommended dosage ranges from 10 mg to 20 mg, taken approximately 30 minutes before sexual activity.
- For BPH, a daily dose of 5 mg is generally prescribed.
Side Effects
- Common side effects include headache, facial flushing, indigestion (nausea, diarrhea), dizziness, muscle pain, and back pain.
- Serious adverse effects, though rare, may include sudden vision or hearing loss.
Contraindications
- Tadalafil should not be co-administered with nitrates (e.g., nitroglycerin) due to the risk of severe hypotension.
- It is contraindicated for individuals with severe heart conditions or those with a recent history of myocardial infarction or stroke.
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يفعل بالتأكيد ما يعد به. فقط ليس دراماتيكياً كما كنت آمل.
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质量不错，但我之前用过稍微好一点的。
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كنت أتوقع أكثر قليلاً مقابل السعر، لكنه جيد رغم ذلك.
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Différence notable après avoir utilisé Lilly Cialis 4 tabs (20 mg/tab). Fantastique !
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Très bon mais pas époustouflant.
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Truly exceptional product.
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Excelentes resultados pero tardó un poco más de lo esperado.
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Produkt von höchster Qualität. Lilly Cialis 4 tabs (20 mg/tab) ist einfach das Beste.
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Buona qualità anche se non così forte come speravo.
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Il Lilly Cialis 4 tabs (20 mg/tab) offre prestazioni eccezionali. Altamente raccomandato!
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Undeniable quality and purity.
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جيد تقريباً مثل علامتي التجارية المعتادة.
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Pharmaceutical grade for sure.
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Bonne qualité bien que pas aussi forte que je l’espérais.
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Très bon produit. Presque parfait.
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After trying this Lilly Cialis 4 tabs (20 mg/tab)
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Fonctionne bien mais un peu cher par rapport à d’autres.
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Life-changing results.
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Хороший продукт. Только незначительные проблемы.
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Vraiment bonne qualité. Je recommanderais.