Oxandrolone – Anavar
Anavar, a popular anabolic steroid, is favored by athletes and bodybuilders alike for its ability to promote weight gain without the conversion to estrogen, significantly reducing the risk of gynecomastia and water retention.
Initially introduced in North America nearly 50 years ago, Anavar has transitioned from treating various infertility disorders and anemia to a niche role in clinical settings. Its unique profile includes no conversion to estrogen and minimal impact on the hypothalamic-pituitary axis, allowing users to avoid common steroid side effects like loss of libido and testicular atrophy.
Pharmacology
Oxandrin, as an anabolic steroid with androgenic properties, mimics testosterone. At lower doses, it exhibits selective anabolic effects; however, higher doses can elicit potent androgenic responses. It may suppress gonadotropin release at elevated doses, affecting testosterone synthesis. Like other anabolic steroids, Anavar can increase LDL cholesterol while decreasing HDL cholesterol, but crucially, it avoids estrogen conversion at low doses.
Indications
Usage in clinical medicine has dwindled, with historical applications for anemia and HIV-related weight loss. Production by Searle ceased in 1989 due to abuse concerns, leading to its manufacture by Savient Pharmaceutical under the name Oxandrin. Some physicians still prescribe Oxandrin for weight gain in serious conditions following trauma or infections, sometimes alongside corticosteroids for bone pain in cancer patients.
Dosage
For anemia or weight gain, the typical adult dosage ranges from 2.5-20 mg/day divided into 2-4 doses. While some may respond to lower doses, others might need between 30-150 mg/day. Treatment duration typically spans 3-6 weeks, with gradual dose adjustments based on responsiveness. Oxandrin tablets are available in 2.5 mg and 10 mg formulations.
Minor side effects, including abdominal discomfort, nausea, and diarrhea, are common at lower doses. However, higher doses may result in more serious issues, such as:
- jaundice
- rare hepatic necrosis
- liver cancer
- general malaise
- testicular atrophy
- hair loss
- breast enlargement
- stomach cramps, nausea, bloating
- acne, oily skin
- diarrhea
- menstrual irregularities
Most side effects are reversible upon discontinuation of the drug.
Contraindications
Oxandrolone should be avoided in patients with:
- suspected prostate cancer
- breast cancer in males or females
- pregnancy
- evidence of hypercalcemia
- allergy to anabolic steroids
Bodybuilders
Anavar is a favored choice among bodybuilders due to its efficient absorption and minimal side effects at low doses. The usual male dosage is one tablet twice daily, while females typically require one tablet daily. Most bodybuilders begin with lower doses and may stack Anavar with other compounds like dianabol, winstrol, or anadriol for enhanced results over 4-8 weeks. Experts often recommend starting at 5 mg/day and increasing gradually over 2-3 weeks.
Women prefer Anavar due to its low virilizing nature, but exceeding 5 mg/day or prolonged use beyond 6 weeks can lead to virilization signs such as:
- deep voice
- decreased libido
- clitoral enlargement
- acne
- excessive hair growth
Immediate cessation is advised if any virilization symptoms occur, as some changes may not be reversible.
Warnings
All anabolic steroids, including Anavar, carry the potential for liver damage, including jaundice and serious conditions such as liver cancer. Regular monitoring of liver enzyme levels and annual ultrasound checks are prudent for anyone using this steroid.
Overdose
While the risk of overdose with anabolic steroids is low, excessive use of Anavar could lead to discomfort, necessitating medical attention. Supportive care is the primary treatment for steroid overdose cases.
Costs
The price for 100 tablets of Anavar (2.5 mg) ranges from $100-$150. However, due to high demand, counterfeit products are prevalent. It’s crucial to obtain Anavar from reliable sources, even if purchasing from foreign markets like Mexico, where quality is uncertain. Authentic Anavar sold through pharmacies can cost between $700-$1200 for 100 tablets.
Levels
Anavar and its metabolites are detectable in urine, with most major sports organizations conducting regular screenings. Metabolites can linger in the system for 7-14 days post-use.
Legal
Anavar is classified as a controlled substance in the USA, prohibiting its sale and distribution. The DEA actively monitors these transactions in pharmacies and online. Possessing Anavar without a clinical purpose is considered illegal in the United States.
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