Tadalafil – Cialis
Tadalafil is a renowned medication belonging to the class of phosphodiesterase type 5 (PDE5) inhibitors. It’s marketed under the trade name Cialis for erectile dysfunction and Adcirca for addressing pulmonary arterial hypertension.
Mechanism of Action
- Tadalafil inhibits the enzyme PDE5, which regulates the breakdown of cyclic guanosine monophosphate (cGMP).
- In response to sexual stimulation, nitric oxide (NO) released in penile tissue elevates cGMP levels.
- This leads to the relaxation of smooth muscle in blood vessels, promoting increased blood flow to facilitate and sustain an erection.
Indications
- Primarily, Tadalafil is prescribed for erectile dysfunction in men.
- Additionally, it manages benign prostatic hyperplasia (BPH) and treats pulmonary arterial hypertension as Adcirca.
Onset of Action
- Typically, Tadalafil shows a quick onset, usually within 30 minutes to an hour post-consumption.
Duration of Action
- Its effects can last up to 36 hours, leading to its nickname as the “weekend pill.”
- This allows men to achieve and maintain an erection during this period with sufficient sexual stimulation.
Dosage
- The standard dose for erectile dysfunction ranges from 10 mg to 20 mg, ideally taken about 30 minutes before anticipated sexual activity.
- A common dosage for BPH treatment is 5 mg daily.
Side Effects
- Frequent side effects may include headaches, flushing, dyspepsia (such as nausea, diarrhea), dizziness, muscle discomfort, and back pain.
- In rare cases, severe side effects like sudden vision or hearing loss may occur.
Dapoxetine
Dapoxetine is a treatment specifically formulated for premature ejaculation in men, marketed under the brand name Priligy.
Mechanism of Action
- As a selective serotonin reuptake inhibitor (SSRI), Dapoxetine helps by delaying the reuptake of serotonin, enhancing its brain availability.
- This increased serotonin enhances control over ejaculation, lengthening the time to reach ejaculation.
Indications
- Dapoxetine is primarily for managing premature ejaculation in men.
- It is suitable for men aged 18 to 64 who experience rapid ejaculation.
Onset of Action
- Expect a rapid response from Dapoxetine, typically occurring within 1 to 2 hours after ingestion.
Duration of Action
- Effects generally last between 4 to 24 hours, subject to the dosage and individual reaction.
Dosage
- The usual dosage ranges from 30 mg to 60 mg, taken as needed.
- Typically starting at 30 mg, physicians may adjust based on patient response.
Side Effects
- Common side effects include dizziness, headaches, nausea, drowsiness, fatigue, and dry mouth.
- Infrequent side effects can involve hot flashes, increased anxiety, behavioral changes, or alterations in sexual function.
Contraindications
- Dapoxetine is contraindicated for individuals with severe liver or kidney concerns, significant heart issues, epilepsy, bipolar disorder, or those on MAO inhibitors.
- Combining Dapoxetine with alcohol should be avoided to minimize potential side effects.
Anonymous (verified owner) –
Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab)完全按照描述运行。太棒了！
Nahoa X. (verified owner) –
Excellent investissement. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) est un excellent produit.
Anonymous (verified owner) –
This Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) is truly remarkable.
Boris W (verified owner) –
تجربة رائعة مع Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab). أوصي به بشدة.
Anonymous (verified owner) –
Absolutely worth the investment.
Anonymous (verified owner) –
Just okay. Nothing special.
Sarawut H (verified owner) –
Meh.
Sofía Z (verified owner) –
Buona roba.
Anonymous (verified owner) –
This Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) is absolutely outstanding.
Natalya W (verified owner) –
فعالية مدهشة. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) يفعل بالضبط ما يعد به.
Anonymous (verified owner) –
Great product but delivery took longer than expected.
Anonymous (verified owner) –
جيد، لكن كان لدي أفضل في الماضي.
Aisha H (verified owner) –
Quasi buono come il mio solito marchio.
Anonymous (verified owner) –
This Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) is truly exceptional.
Platon T (verified owner) –
Definitiv überdurchschnittlich.
Ebru U. (verified owner) –
Una inversión que vale cada centavo. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) es excepcional.
Achraf X. (verified owner) –
Hace su trabajo pero no es impresionante.
Danish L (verified owner) –
نتائج جيدة جداً بعد الاستخدام المستمر.
Narek G (verified owner) –
Envio rápido e produto de qualidade. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) é perfeito.
Anonymous (verified owner) –
يعمل كما هو معلن عنه. لا مفاجآت.
Omar H (verified owner) –
جودة فوق المتوسط. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) استثنائي.
Anonymous (verified owner) –
La qualità di Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) è immediatamente evidente. Perfetto!
Suhana S (verified owner) –
Produit de qualité mais livraison un peu lente.
Yan Z (verified owner) –
No complaints. Does the job well.
Anonymous (verified owner) –
جودة Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) واضحة على الفور. ممتاز!
Anonymous (verified owner) –
Definitivamente por encima del promedio.
Anonymous (verified owner) –
The pinnacle of supplementation.
Anonymous (verified owner) –
The gold standard of supplements.
Anonymous (verified owner) –
لا بأس به. ربما أجرب شيئاً آخر المرة القادمة.
Alkina E. (verified owner) –
Mediocre en el mejor de los casos.
Anonymous (verified owner) –
Produto muito satisfatório.
Gerhard B (verified owner) –
راضٍ بشكل عام عن مشترياتي.
Anonymous (verified owner) –
Remarkable stuff.
Sophie S (verified owner) –
Excelente custo-benefício. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) vale cada centavo.
Anonymous (verified owner) –
Qualité douteuse. Très faible.
Vihaan L. (verified owner) –
Dramatic increase in strength.
Anonymous (verified owner) –
Perfect purity. Lab results match exactly.
George U. (verified owner) –
差不多符合我的期望。不错的产品。
Anonymous (verified owner) –
Действительно хорошее качество. Рекомендовал бы.
Anonymous (verified owner) –
效果令人印象深刻，但我期望更多。
Anonymous (verified owner) –
منتج جيد. مشاكل طفيفة فقط.
Ariel S (verified owner) –
Achat solide. Majoritairement satisfait.
Anonymous (verified owner) –
نتائج مقبولة. كنت أتوقع أفضل مقابل السعر.
Anonymous (verified owner) –
Absolutely superior product.
Serdar V (verified owner) –
Globalement satisfait de mon achat.
Anonymous (verified owner) –
Produit de première qualité. Sunrise Extra Super Tadarise 10 tabs (40 + 60 mg/tab) est excellent.
Anonymous (verified owner) –
Никаких жалоб. Делает свою работу хорошо.
Serge I (verified owner) –
No corners cut on quality.
Arzygul K (verified owner) –
You can feel the quality immediately.