Dapoxetine
Dapoxetine, marketed as Priligy, is a medication designed to address premature ejaculation in men.
Mechanism of Action
- Dapoxetine is classified as a selective serotonin reuptake inhibitor (SSRI).
- This drug works by delaying the reabsorption of serotonin, enhancing its availability in the brain.
- Elevated serotonin levels improve control over ejaculation, promoting extended duration before climax.
Indications
- Dapoxetine is primarily targeted for men experiencing premature ejaculation.
- Indicated for males aged 18 to 64 with concerns regarding rapid ejaculation.
Onset of Action
- Dapoxetine exhibits a swift effect, typically manifesting within 1 to 2 hours post-ingestion.
Duration of Action
- The effects of dapoxetine generally persist for 4 to 24 hours, influenced by dosage and patient response.
Dosage
- The standard dosage of dapoxetine ranges from 30 mg to 60 mg, taken as required.
- Initial recommended dosage usually starts at 30 mg, with potential adjustments made by a healthcare professional.
Side Effects
- Common side effects include dizziness, headaches, nausea, drowsiness, fatigue, and dry mouth.
- Occasionally, side effects such as hot flashes, anxiety, behavioral changes, or alterations in sexual function may arise.
Contraindications
- Dapoxetine is contraindicated for individuals with severe liver or kidney impairment, serious heart conditions, epilepsy, bipolar disorder, or those taking monoamine oxidase inhibitors (MAOIs).
- Avoiding combination with alcohol is essential to reduce side effect risks.
Avanafil
Avanafil, also recognized as Stendra, is an effective treatment for erectile dysfunction in men, belonging to the class of phosphodiesterase type 5 (PDE5) inhibitors.
Mechanism of Action
- Avanafil enhances blood flow to the penis during arousal by inhibiting the enzyme PDE5, leading to relaxation of smooth muscles in the penile blood vessels, facilitating erection.
Rapid Onset of Action
- This medication is known for its quick effects, typically observable within 15 to 30 minutes post-administration, outperforming many counterparts for similar issues.
Duration of Action
- The effects of avanafil can last between 4 to 6 hours, allowing sufficient time for satisfactory sexual activity.
Dosage
- The initial recommended dose is 100 mg, which can be customized up to 200 mg or down to 50 mg based on individual needs and responses.
Side Effects
- Common side effects include headaches, facial flushing, gastrointestinal issues (such as nausea and diarrhea), dizziness, and elevated blood pressure. Rarely, hearing loss or vision changes may occur.
Contraindications
- Avanafil should not be taken alongside nitrates or similar medications and is not recommended for men with serious heart conditions or those who have recently suffered a heart attack or stroke.
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